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Merck

MABN269

Anti-IRF8 Antibody, clone 8C6.2

clone 8C6.2, from mouse

Synonym(s):

Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein, H-ICSBP, ICSBP

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-IRF8 Antibody, clone 8C6.2, clone 8C6.2, from mouse

biological source

mouse

antibody product type

primary antibodies

clone

8C6.2, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgMκ

NCBI accession no.

NP_002154

UniProt accession no.

Q02556

shipped in

wet ice

Quality Level

100

Gene Information

human ... IRF8(3394)

Analysis Note

Control
THP-1 cell lysate
Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected IRF8 in 10 µg of THP-1 cell lysate.

Application

Detect IRF-8 using this mouse monoclonal antibody, Anti-IRF8 Antibody, clone 8C6.2 validated for use in western blotting & IHC.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected IRF8 in 10 µg of human spleen tissue lysate.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected IRF8 in 10 µg of Jurkat cell lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected IRF8 in human tonsil tissue.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Interferon regulatory factor 8 (IRF-8) is also known as interferon consensus sequence-binding protein. Interferon regulatory factors (IRFs) comprise a family of transcription factors that function with the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRF-8 specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes at the interferon consensus sequence (ICS). IRF-8 has a negative regulatory function in immune cells, can be induced by IFNG/ IFN-gamma and is involved in CD8+ dendritic cell differentiation. IRF-8 is predominantly expressed in lymphoid tissues. IRF-8 is implicated in MS.
~48 kDa observed

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Immunogen

Linear peptide corresponding to human IRF8.

Physical form

Format: Purified
Purified by Ion-Exchange Chromatography
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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