AB10302
Anti-PXR Antibody
serum, Chemicon®
Synonym(s):
Pregnane X receptor
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Product Name
Anti-PXR Antibody, serum, Chemicon®
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Quality Level
Analysis Note
Routinely evaluated by immunoblot.
Application
Suggested dilutions:
Western Blot: 1:5000
Western Blot: 1:5000
Anti-PXR Antibody is an antibody against PXR for use in WB.
Research Category
Metabolism
Metabolism
Research Sub Category
Toxicology & Drug Resistance
Toxicology & Drug Resistance
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
50kDa
Pregnane X receptor (PXR) is a nuclear receptor and is similar in form to PPAR and RXR. PXR is activated by a large number of endogenous and exogenous chemicals including steroids and antibiotics. One of the key roles of PXR is the induction of CYP3A4, an P450 enzyme that is responsible for the metabolism of many drugs.
Immunogen
Recombinant human hPXR
Physical form
Raw rabbit serum with 0.1% sodium azide.
Preparation Note
Maintain at 2-8°C for up to 12 months from date of receipt.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk
WGK 1
Certificates of Analysis (COA)
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Pregnane X receptor and natural products: beyond drug-drug interactions
Staudinger, Jeff L, et al
Expert Opinion on Drug Metabolism & Toxicology, 2, 847-857 (2006)
Xiaochao Ma et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(2), 194-200 (2006-11-10)
The most common clinical implication for the activation of the human pregnane X receptor (PXR) is the occurrence of drug-drug interactions mediated by up-regulated cytochromes P450 3A (CYP3A) isozymes. Typical rodent models do not predict drug-drug interactions mediated by human
Junko Sugatani et al.
Drug metabolism and disposition: the biological fate of chemicals, 44(1), 137-150 (2015-11-05)
The human pregnane X receptor (hPXR) is a xenobiotic-sensing nuclear receptor that transcriptionally regulates drug metabolism-related genes. The aim of the present study was to elucidate the mechanism by which hPXR is regulated through threonine-408. A phosphomimetic mutation at threonine-408
Modulation of pregnane X receptor-and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds
Kluth, Dirk, et al
Free radical biology & medicine, 42, 315-325 (2007)
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