AB1572

Anti-GABA Transporter-2 Antibody

Name: Anti-GABA Transporter-2 Antibody
Brand: MM

Chemicon^®, from rabbit

Synonym(s):

GAT-2

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-GABA Transporter-2 Antibody, Chemicon^®, from rabbit

antibody form

affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat

manufacturer/tradename

Chemicon^®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_016615.2

UniProt accession no.

Q9NSD5

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

mouse ... Slc6A13(14412)
rat ... Slc6A13(171163)

Application

Research Category
Neuroscience

Immunohistochemistry: 1:500-1:750 on 4% paraformaldehyde fixed tissue.

It is recommended that the antibody is diluted in PBS containing 10% normal goat serum and 0.5% Triton X-100. AB1572 has been used for light microscopic studies of the rat nervous system.

Western blot: It has been reported that this antibody works for Western blot (Conti, 1999).

Optimal working dilutions must be determined by the end user.

Research Sub Category
Ion Channels & Transporters

This Anti-GABA Transporter-2 Antibody is validated for use in IH, WB for the detection of GABA Transporter-2.

Biochem/physiol Actions

GABA Transporter-2 (GAT-2), C-terminus. No cross-reactivity to the C-termini of other transmitter transporters detected.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

GAT-2, C-terminus (aa 593-602)

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified antibody. Purified in PBS with 0.1% sodium azide.

Preparation Note

Maintain lyophilized material at 2-8°C for up to 12 months. Maintain reconstituted material at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H412

pcodes

P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Early VGLUT1-specific parallel fiber synaptic deficits and dysregulated cerebellar circuit in the KIKO mouse model of Friedreich ataxia.

Hong Lin et al.

Disease models & mechanisms, 10(12), 1529-1538 (2017-12-21)

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder with progressive ataxia that affects both the peripheral and central nervous system (CNS). While later CNS neuropathology involves loss of large principal neurons and glutamatergic and GABAergic synaptic terminals in the

Arid1b haploinsufficiency in parvalbumin- or somatostatin-expressing interneurons leads to distinct ASD-like and ID-like behavior.

Amanda L Smith et al.

Scientific reports, 10(1), 7834-7834 (2020-05-14)

Inhibitory interneurons are essential for proper brain development and function. Dysfunction of interneurons is implicated in several neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability (ID). We have previously shown that Arid1b haploinsufficiency interferes with interneuron development and

Global Trade Item Number

SKU	GTIN
AB1572	04053252730276

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