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AB4326

Anti-ISL-1 Antibody

Name: Anti-ISL-1 Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

ISL LIM homeobox 1, ISL1 transcription factor, LIM/homeodomain, ISL1 transcription factor, LIM/homeodomain, (islet-1)

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ICC, IHC, WB

Citations:

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

horse, human, mouse

species reactivity (predicted by homology)

sheep (based on 100% sequence homology), canine (based on 100% sequence homology), rat (based on 100% sequence homology), equine (based on 100% sequence homology), bovine (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

NP_002193

UniProt accession no.

P61371

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ISL1(3670)

Description

General description

Islet-1 (ISL-1) is a transcription factor that plays an important role in the embryogenesis of pancreatic islets of Langerhans. It is expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. In mouse embryos, a deficiency of this gene fail to undergo neural tube motor neuron differentiation. More recently it has been identified as a marker for a cardiac progenitor cell lineage that is capable of differentiating into all 3 major heart cell types: cardiomyocytes, smooth muscle and endothelial cell lineages.

~39 kDa

Immunogen

Epitope: Internal region of ISL-1.

KLH-conjugated linear peptide corresponding to human ISL-1.

Application

Anti-ISL-1 Antibody is a Rabbit Polyclonal Antibody for detection of ISL-1 also known as ISL LIM homeobox 1, ISL1 transcription factor LIM/homeodomain & has been validated in WB & IHC.

Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected ISL-1 in mouse pancreas tissue.

Biochem/physiol Actions

Predicted to react with most common vertebrate species based on 100% sequence homology.

This antibody recognizes ISL-1.

Analysis Note

Evaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected ISL-1 on 10 µg of K562 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c