AB9210

Anti-Insulin Degrading Enzyme Antibody

Name: Anti-Insulin Degrading Enzyme Antibody
Brand: MM

serum, Chemicon^®

Synonym(s):

IDE, Insulysin, Insulinase

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Insulin Degrading Enzyme Antibody, serum, Chemicon^®

biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat

packaging

antibody small pack of 25 μL

manufacturer/tradename

Chemicon^®

technique(s)

western blot: suitable

NCBI accession no.

NM_004969.2

UniProt accession no.

P14735

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Analysis Note

Tested

Application

Anti-Insulin Degrading Enzyme Antibody is an antibody against Insulin Degrading Enzyme for use in WB.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Western blotting: 1:10,000-1:20,000. The antibody recognizes a protein of ~110 kDa on rat liver tissue lysate.

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Insulin Degrading Enzyme (IDE). It is expected that the antibody will also react with human and mouse due to immunogen sequence homology.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Synthetic peptide from rat IDE.

Other Notes

feature_concentration_valuePlease refer to lot specific datasheet.

Physical form

Rabbit serum. Liquid.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice.

Beatriz Merino et al.

Metabolism: clinical and experimental, 113, 154352-154352 (2020-09-12)

The insulin-degrading enzyme (IDE) is a metalloendopeptidase with a high affinity for insulin. Human genetic polymorphisms in Ide have been linked to increased risk for T2DM. In mice, hepatic Ide ablation causes glucose intolerance and insulin resistance when mice are

Effects of Fasting and Feeding on Transcriptional and Posttranscriptional Regulation of Insulin-Degrading Enzyme in Mice.

Carlos M González-Casimiro et al.

Cells, 10(9) (2021-09-29)

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed Zn2+-metallopeptidase that regulates hepatic insulin sensitivity, albeit its regulation in response to the fasting-to-postprandial transition is poorly understood. In this work, we studied the regulation of IDE mRNA and protein

Evolutionary Origin of Insulin-Degrading Enzyme and Its Subcellular Localization and Secretion Mechanism: A Study in Microglial Cells.

Miriam Corraliza-Gómez et al.

Cells, 11(2) (2022-01-22)

The insulin-degrading enzyme (IDE) is a zinc-dependent metalloendopeptidase that belongs to the M16A metalloprotease family. IDE is markedly expressed in the brain, where it is particularly relevant due to its in vitro amyloid beta (Aβ)-degrading activity. The subcellular localization of

In Vitro Astroglial Dysfunction Induced by Neurotoxins: Mimicking Astrocytic Metabolic Alterations of Alzheimer's Disease.

Jéssica Taday et al.

Metabolites, 14(3) (2024-03-27)

Astrocytes play fundamental roles in the maintenance of brain homeostasis. The dysfunction of these cells is widely associated with brain disorders, which are often characterized by variations in the astrocyte protein markers GFAP and S100B, in addition to alterations in

Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice.

Enrique Jurado-Ruiz et al.

Scientific reports, 9(1), 11311-11311 (2019-08-07)

Dietary composition plays an important role in the pathophysiology of type 2 diabetes. Monounsaturated fatty acid consumption has been positively associated with improved insulin sensitivity and β-cell function. We examined whether an extra virgin olive oil (EVOO) high fat diet

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Global Trade Item Number

SKU	GTIN
AB9210	04053252324475
AB9210-25UL	04054839337406

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