Anti-CAPS-1 Antibody

CAPS-1 and its related protein CAPS-2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS-1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.

~153 kDa observed. Uncharacterized bands may appear between ~30 kDa and ~110 kDa in some lysates.

KLH-conjugated linear peptide corresponding to human CAPS-1.

Anti-CAPS-1 detects levels of CAPS-1 proteins & has been published & validated for use in WB & IHC.

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected CAPS-1 in rat hippocampus and cerebral cortex tissues.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

This antibody is predicted to be specific to CAPS-1 and not recognize CAPS-2.

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Mouse brain membrane tissue lysate

Evaluated by Western Blot in mouse brain membrane tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected CAPS-1 in 10 µg/mL of mouse brain membrane tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.