CBL243

Anti-Glucose Transporter GLUT-4 Antibody

Name: Anti-Glucose Transporter GLUT-4 Antibody
Brand: MM

Chemicon^®, from rabbit

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human, rat

manufacturer/tradename

Chemicon^®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_001042.2

UniProt accession no.

P14672

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SLC2A4(6517)

General description

46 kDa

Immunogen

Partially purified GLUT-4

Application

Research Category
Signaling

Research Sub Category
Insulin/Energy Signaling

This Anti-Glucose Transporter GLUT-4 Antibody is validated for use in IP, WB for the detection of Glucose Transporter GLUT-4.

Western blot analysis of GLUT-4 activity in adipose and muscle tissue (5μg/ml)

Immunoprecipitation of GLUT-4 (5μg/ml)

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Specific for human glucose transporter-4 from muscle and adipose tissue. The antisera does not cross-react with GLUT-1. The molecular weight of the glucose transporter precipitated by the serum is approximately 46 kDa.

Physical form

ImmunoAffinity Purified

Purified immunoglobulin in PBS with 0.01% sodium azide.

Preparation Note

For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.

Analysis Note

Control
Positive Control: 3T3 L1 adipocyte membranes

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Exercise effects on γ3-AMPK activity, Akt substrate of 160 kDa phosphorylation, and glucose uptake in muscle of normal and insulin-resistant female rats.

Haiyan Wang et al.

Journal of applied physiology (Bethesda, Md. : 1985), 132(1), 140-153 (2021-12-10)

Previous studies demonstrated that acute exercise can enhance glucose uptake (GU), γ3-AMP-activated protein kinase (AMPK) activity, and Akt substrate of 160 kDa (AS160) phosphorylation in skeletal muscles from low-fat diet (LFD)- and high-fat diet (HFD)-fed male rats. Because little is

Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal muscle from 26-month-old rats.

Haiyan Wang et al.

Facets (Ottawa), 7, 774-791 (2022-11-17)

Attenuated skeletal muscle glucose uptake (GU) has been observed with advancing age. It is important to elucidate the mechanisms linked to interventions that oppose this detrimental outcome. Earlier research using young rodents and (or) cultured myocytes reported that treatment with

Exercise restores insulin, but not adiponectin, response in skeletal muscle of high-fat fed rodents.

Roberto A Gulli et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 303(10), R1062-R1070 (2012-10-12)

High-fat (HF) diets impair skeletal muscle response to the insulin-sensitizing adipokine adiponectin (Ad) in rodents, preceding the development of insulin resistance. Skeletal muscle insulin response in HF-fed rats can be restored with chronic exercise; whether recovery of skeletal muscle Ad

In vivo glucoregulation and tissue-specific glucose uptake in female Akt substrate 160 kDa knockout rats.

Xiaohua Zheng et al.

PloS one, 15(2), e0223340-e0223340 (2020-02-14)

The Rab GTPase activating protein known as Akt substrate of 160 kDa (AS160 or TBC1D4) regulates insulin-stimulated glucose uptake in skeletal muscle, the heart, and white adipose tissue (WAT). A novel rat AS160-knockout (AS160-KO) was created with CRISPR/Cas9 technology. Because

Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction's effect on glucose uptake in skeletal muscle.

Naveen Sharma et al.

Biochimica et biophysica acta, 1822(11), 1735-1740 (2012-08-01)

Calorie restriction (CR; ~60% of ad libitum, AL, consumption) improves insulin-stimulated glucose uptake in skeletal muscle. The precise cellular mechanism for this healthful outcome is unknown, but it is accompanied by enhanced insulin-stimulated activation of Akt. Previous research using Akt2-null

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Global Trade Item Number

SKU	GTIN
CBL243	04053252322280

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