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Merck

DR1001

Anti-8-Hydroxyguanosine Goat pAb

liquid, Calbiochem®

Synonym(s):

Anti-8-OHG, Anti-8-oxo-G

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About This Item

NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
polyclonal
Application:
Citations:
2

Key Documents

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Product Name

Anti-8-Hydroxyguanosine Goat pAb, liquid, Calbiochem®

biological source

goat

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

form

liquid

does not contain

preservative

species reactivity (predicted by homology)

all

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

dilution

(ELISA (1:250,000)
Paraffin Sections (1:200, proteinase K pre-treatment recommended; see figure legend, )

isotype

IgG

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Analysis Note

Positive Control
Alzheimer’s disease brain tissue

Application


ELISA (≥1:250,000)
Paraffin Sections (≥1:200, proteinase K pre-treatment recommended; see figure legend, see application references)

Disclaimer

Toxicity: Standard Handling (A)

General description

Goat polyclonal antibody supplied as undiluted serum. Recognizes 8-hydroxydeoxy-guanosine.
Recognizes 8-Hydroxydeoxyguanosine in Alzheimer′s disease brain tissue.
This Anti-8-Hydroxyguanosine Goat polyclonal antibody detects 8-Hydroxydeoxyguanosine in Alzheimer′s disease brain tissue. It is validated for use in ELISA and with paraffin sections.

Immunogen

8-Hydroxyguanosine

Other Notes

Abe, T., et al. 2003. Neurosci. Lett.336, 105.
Parker, A.R., et al. 2002. Cancer Res.62, 7230.
Does not cross-react with other naturally occurring nucleotides. Antibody should be titrated for optimal results in individual systems.

Physical form

Undiluted serum.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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N Gueven et al.
Cell death and differentiation, 14(6), 1149-1161 (2007-03-10)
Several different autosomal recessive genetic disorders characterized by ataxia with oculomotor apraxia (AOA) have been identified with the unifying feature of defective DNA damage recognition and/or repair. We describe here the characterization of a novel form of AOA showing increased
Joseph J Boyle et al.
The American journal of pathology, 174(3), 1097-1108 (2009-02-24)
Intraplaque hemorrhage accelerates atherosclerosis via oxidant stress and contributes to lesion development and destabilization. Normally, macrophages scavenge hemoglobin-haptoglobin (HbHp) complexes via CD163, and this process provokes the secretion of the anti-inflammatory atheroprotective cytokine interleukin (IL)-10. We therefore tested the hypothesis

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