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Merck

HPRTKMAG-01K

MILLIPLEX® RTK Phosphoprotein Signaling Panel

Configurable RTK Phosphoprotein 16-Plex Cell Signaling Panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000

Key Documents

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species reactivity

human

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

General description

This panel targets phosphorylated receptor tyrosine kinases (RTKs), which are essential mediators of cell signaling in response to growth factors and cytokines. RTKs such as EGFR, HER2, VEGFR, and PDGFR regulate pathways involved in cell proliferation, survival, and differentiation. Aberrant RTK activation is associated with cancer, making this panel valuable for oncology and signal transduction research.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 16 analytes in cell lysate samples.

Analytes Included: phosphorylated (panTyr) c-Kit, c-Met/HGFR, EGFR, ErbB2/HER2, ErbB3/HER3 , ErbB4/HER4 , FGFR1 , FLT3 , IGF-1R, M-CSFR, PDGFRβ, TIE1, TIE2, VEGFR1, VEGFR2, and VEGFR3

Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, buffer compatibility, lysate control, and recommended loading control (MAPmate™ Control Assays).

Features and Benefits

  • Simultaneously detect multiple phosphorylated receptor tyrosine kinases (RTKs) involved in cell growth, survival, and differentiation
  • Includes key RTKs such as EGFR, HER2, VEGFR, PDGFR, and others
  • Magnetic bead-based format ensures reproducibility and efficient processing
  • Compatible with cell lysates from cancer, immunology, and signal transduction studies• Ideal for oncology, drug discovery, and receptor signaling research
  • Fast, convenient alternative to Western Blotting and immunoprecipitation procedures

Legal Information

Luminex is a registered trademark of Luminex Corp
MAPMATE is a trademark of Merck KGaA, Darmstadt, Germany
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Storage Class

10 - Combustible liquids

wgk

WGK 3

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - ED ENV 1 - Eye Dam. 1 - Skin Irrit. 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Adam Stewart et al.
Molecular cancer therapeutics, 18(8), 1396-1404 (2019-07-03)
It is increasingly appreciated that drug response to different cancers driven by the same oncogene is different and may relate to differences in rewiring of signal transduction. We aimed to study differences in dynamic signaling changes within mutant KRAS (KRAS
Elizabeth A Coker et al.
Molecular cancer therapeutics, 21(6), 1020-1029 (2022-04-04)
We hypothesize that the study of acute protein perturbation in signal transduction by targeted anticancer drugs can predict drug sensitivity of these agents used as single agents and rational combination therapy. We assayed dynamic changes in 52 phosphoproteins caused by
Ahmet Acar et al.
Nature communications, 11(1), 1923-1923 (2020-04-23)
Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer therapy today. However, evolving resistance to one drug may come at a cost of decreased fecundity or increased sensitivity to another drug. These evolutionary trade-offs can be

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Global Trade Item Number

SKUGTIN
HPRTKMAG-01K-0704054839035616
HPRTKMAG-01K-0904054839035630
HPRTKMAG-01K-1004054839035647
HPRTKMAG-01K-1104054839035654
HPRTKMAG-01K-0104054839035241
HPRTKMAG-01K-0204054839035258
HPRTKMAG-01K-0604054839035296
HPRTKMAG-01K-1504054839035692
HPRTKMAG-01K-0304054839035265
HPRTKMAG-01K-0804054839035623
HPRTKMAG-01K-1804054839035722
HPRTKMAG-01K-0404054839035272
HPRTKMAG-01K-1704054839035715
HPRTKMAG-01K-0504054839035289
HPRTKMAG-01K-1204054839035661
HPRTKMAG-01K-1304054839035678
HPRTKMAG-01K-1404054839035685
HPRTKMAG-01K-1604054839035708

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