MAB1572
Anti-Parvalbumin Antibody
CHEMICON®, mouse monoclonal, PARV-19
Synonym(s):
Anti-D22S749
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Product Name
Anti-Parvalbumin Antibody, ascites fluid, clone PARV-19, Chemicon®
biological source
mouse
antibody form
ascites fluid
antibody product type
primary antibodies
clone
PARV-19, monoclonal
species reactivity
feline, rabbit, goat, frog, fish, human, pig, bovine, rat, mouse, canine
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PVALB(5816)
Physical form
Ascites mouse monoclonal IgG1 liquid
Unpurified
Preparation Note
Stable for 1 year at -20ºC from date of receipt.
Analysis Note
Control
Brain tissue, Cultured neurons
Brain tissue, Cultured neurons
Routinely evaluated by Western Blot on mouse brain lysate.
Western Blot Analysis:
1:1000 dilution of this lot detected Parvalbumin on 10 μg of mouse brain lysate.
Western Blot Analysis:
1:1000 dilution of this lot detected Parvalbumin on 10 μg of mouse brain lysate.
Application
Anti-Parvalbumin Antibody is an antibody against Parvalbumin for use in IC, IH(P) & WB.
Immunohistochemistry:
A previous lot was used by indirect immunoperoxidase at 1:1,000-1:2,000 dilution. The antibody works on formalin fixed, paraffin embedded tissue sections of rat cerebellum from a previous lot. Fixation does not appear to affect MAB1572’s ability to detect parvalbumin.
Immunocytochemistry:
A previous lot of this antibody was used on cultured neurons.
Optimal working dilutions must be determined by the end user.
A previous lot was used by indirect immunoperoxidase at 1:1,000-1:2,000 dilution. The antibody works on formalin fixed, paraffin embedded tissue sections of rat cerebellum from a previous lot. Fixation does not appear to affect MAB1572’s ability to detect parvalbumin.
Immunocytochemistry:
A previous lot of this antibody was used on cultured neurons.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
Biochem/physiol Actions
Parvalbumin. The antibody will react with parvalbumin from brain and muscle. By immunoblot it recognizes a protein of 12 kDa. The antibody is directed against an epitope at the first Ca+2-binding site and specifically stains the Ca+2 -bound form of parvalbumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
12 kDa
Parvalbumin is a calcium binding albumin protein. It has three EF hand motifs and is structurally related to calmodulin and troponin C. Parvalbumin is localised in fast-contracting muscles, where its levels are highest, and in the brain and some endocrine tissues. Parvalbumin is present in GABAergic interneurons in the nervous system, predominantly expressed by chandelier and basket cells in the cortex.
Immunogen
Parvalbumin purified from frog muscle
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death.
Robert Esterberg et al.
The Journal of clinical investigation, 126(9), 3556-3566 (2016-08-09)
Exposure to aminoglycoside antibiotics can lead to the generation of toxic levels of reactive oxygen species (ROS) within mechanosensory hair cells of the inner ear that have been implicated in hearing and balance disorders. Better understanding of the origin of
Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network.
Hu, W; Zhang, M; Czeh, B; Flugge, G; Zhang, W
Neuropsychopharmacology null
Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex.
Runyan, CA; Schummers, J; Van Wart, A; Kuhlman, SJ; Wilson, NR; Huang, ZJ; Sur, M
Neuron null
The use of PRV-Bartha to define premotor inputs to lumbar motoneurons in the neonatal spinal cord of the mouse.
Jovanovic, K; Pastor, AM; O'Donovan, MJ
Testing null
Patricia R Jusuf et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(7), 2549-2562 (2011-02-18)
Multipotent progenitors in the vertebrate retina often generate clonally related mixtures of excitatory and inhibitory neurons. The postmitotically expressed transcription factor, Ptf1a, is essential for all inhibitory fates in the zebrafish retina, including three types of horizontal and 28 types
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MAB1572 | 08436037125669 |
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