MAB1876

Anti-Integrin αVβ6 Antibody

Name: Anti-Integrin αVβ6 Antibody
Brand: MM

CHEMICON^®, mouse monoclonal, 27.1 (VNR-1)

Synonym(s):

CD51/CD61, VNR-1

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

Product Name

Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1), clone 27.1 (VNR-1), Chemicon^®, from mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

27.1 (VNR-1), monoclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

technique(s)

immunofluorescence: suitable
immunoprecipitation (IP): suitable

isotype

IgG1

NCBI accession no.

NM_002210.2

UniProt accession no.

P06756

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ITGAV(3685)

Application

Anti-Integrin αVβ3 Antibody, clone 27.1 (VNR-1) detects level of Integrin αVβ3 & has been published & validated for use in IF & IP.

Immunohistochemistry: 4-10% formalin fixed frozen tissues (short fixation times, 10 minutes room temperature) only; not effective on paraffin embedded tissues

Immunoprecipitation

Functional blocking: Competes with clone LM609 for integrin function blocking.

Optimal working dilutions must be determined by end user.

Research Category
Cell Structure

Research Sub Category
Integrins

Biochem/physiol Actions

Reacts with the human integrin alphaVbeta3. Shown to be specific for alphaVbeta3 by Loftus JC et al (1990) Science 249:915-918.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Protein A purified mouse immunoglobulin in liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% sodium azide.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Developing an Injectable Nanofibrous Extracellular Matrix Hydrogel With an Integrin αvβ3 Ligand to Improve Endothelial Cell Survival, Engraftment and Vascularization.

Dake Hao et al.

Frontiers in bioengineering and biotechnology, 8, 890-890 (2020-08-28)

Endothelial cell (EC) transplantation via injectable collagen hydrogel has received much attention as a potential treatment for various vascular diseases. However, the therapeutic effect of transplanted ECs is limited by their poor viability, which partially occurs as a result of

Role of phosphatidylserine receptors in enveloped virus infection.

Kouki Morizono et al.

Journal of virology, 88(8), 4275-4290 (2014-01-31)

We recently demonstrated that a soluble protein, Gas6, can facilitate viral entry by bridging viral envelope phosphatidylserine to Axl, a receptor tyrosine kinase expressed on target cells. The interaction between phosphatidylserine, Gas6, and Axl was originally shown to be a

Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation.

Handong Ma et al.

Cell reports, 30(3), 793-806 (2020-01-23)

Periostin is a multifunctional extracellular matrix protein involved in various inflammatory diseases and tumor metastasis; however, evidence regarding whether and how periostin actively contributes to inflammation-associated tumorigenesis remains elusive. Here, we demonstrate that periostin deficiency significantly inhibits the occurrence of

Global Trade Item Number

SKU	GTIN
MAB1876	04053252616778

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