MAB1982

Anti-Integrin α6 Antibody, clone MA6

Name: Anti-Integrin α6 Antibody, clone MA6
Brand: MM

clone MA6, Chemicon^®, from rat

Synonym(s):

CD49f

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Integrin α6 Antibody, clone MA6, clone MA6, Chemicon^®, from rat

biological source

rat

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MA6, monoclonal

species reactivity

mouse

manufacturer/tradename

Chemicon^®

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG2κ

suitability

not suitable for Western blot

NCBI accession no.

NM_000210.2
NM_001079818.1

UniProt accession no.

P23229

shipped in

wet ice

target post-translational modification

unmodified

Application

Immunoprecipitation, flow cytometry, immunohistochemistry in frozen tissue sections. Product does not detect alpha 6 in Western blot since the epitope most likely involves both alpha 6 and beta 1 integrin subunit. Product does not block alpha 6 integrin mediated cell adhesion to laminin. Activation of integrin signaling properties by MA6 has not been characterized. Immunoprecipitation of VLA-6 from lysate of 10E6 cell equivalent requires 2 μg of MA6. Recommended concentration for flow cytometry - 10 μg/mL, staining of frozen tissue sections - 20 μg/mL.

Optimal working dilutions must be determined by end user.

Cell lines tested by using MA6 to express (6 integrins include: mouse bone marrow-derived mast cells, melanoma cell line B16F1, squamous carcinoma SCC-VII, fibroblast cell line NIH-3T3, splenic T lymphocytes, thymocytes and various T cell lines.

This Anti-Integrin α6 Antibody, clone MA6 is validated for use in FC, IP, IH for the detection of Integrin α6.

Biochem/physiol Actions

Reacts with the laminin receptor alpha-6beta-1 and alpha-6beta-4 complexes.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Liquid in 0.02M Phosphate buffer, pH 7.6, with 0.25M NaCl and 0.1% sodium azide.

Preparation Note

Store at +2-8°C for up to 12 months.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mural Wnt/β-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation.

Saptarshi Biswas et al.

Development (Cambridge, England), 149(17) (2022-09-14)

Neurovascular unit and barrier maturation rely on vascular basement membrane (vBM) composition. Laminins, a major vBM component, are crucial for these processes, yet the signaling pathway(s) that regulate their expression remain unknown. Here, we show that mural cells have active

Global Trade Item Number

SKU	GTIN
MAB1982	04053252724695

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