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Merck

MAB2168

Anti-Huntingtin Disease (HD/HTT) Antibody

CHEMICON®, mouse monoclonal, HU-2E8

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Product Name

Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8, ascites fluid, clone HU-2E8, Chemicon®

biological source

mouse

antibody form

ascites fluid

antibody product type

primary antibodies

clone

HU-2E8, monoclonal

species reactivity

monkey, human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_002111.6

UniProt accession no.

P42858

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... HTT(3064), SLC6A4(6532)

Application

Research Sub Category
Neurodegenerative Diseases
Anti-Huntingtin Protein Antibody, a.a. 2146-2541, clone HU-2E8 is an antibody against Huntingtin Protein for use in ELISA, WB, IC, IH(P).
ELISA: 1:500-1:5,000

Western blot: 1:500-1:5,000

Immunohistochemistry on frozen and microwave oven treated paraffin sections

(human tissue): 1:500-1:5,000

Immunocytochemistry on transfected cells: 1:500-1:5,000

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience

Biochem/physiol Actions

Reacts with Huntingtin protein from human and monkey. Weak to no reactivity with mouse. Has not been tested on other species.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Epitope: a.a. 2146-2541
Human huntingtin fragment from aa 2146 to 2541 as a fusion protein.

Physical form

Ascites fluid. Liquid, does not contain any preservative.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Increased apoptosis, Huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington's disease subjects.
Ciammola, A; Sassone, J; Alberti, L; Meola, G; Mancinelli, E; Russo, MA; Squitieri, F; Silani, V
Cell Death and Differentiation null
Wei Li et al.
The Journal of biological chemistry, 281(23), 15916-15922 (2006-04-06)
Huntington disease is an inherited neurodegenerative disorder that is caused by expanded CAG trinucleotide repeats, resulting in a polyglutamine stretch of >37 on the N terminus of the protein huntingtin (htt). htt is a large (347 kDa), ubiquitously expressed protein.
Ellen Sapp et al.
The Journal of biological chemistry, 287(16), 13487-13499 (2012-03-01)
Huntington disease (HD) is caused by polyglutamine expansion in the N terminus of huntingtin (htt). Analysis of human postmortem brain lysates by SDS-PAGE and Western blot reveals htt as full-length and fragmented. Here we used Blue Native PAGE (BNP) and
Amber L Southwell et al.
Human molecular genetics, 26(6), 1115-1132 (2017-01-21)
Huntington disease (HD) is a neurodegenerative disease caused by a mutation in the huntingtin (HTT) gene. HTT is a large protein, interacts with many partners and is involved in many cellular pathways, which are perturbed in HD. Therapies targeting HTT
Hiroki Takano et al.
BMC neuroscience, 3, 15-15 (2002-10-16)
Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine disorders also implies a role for the protein's unknown inherent function. Huntingtin is moderately conserved, with 10
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Global Trade Item Number

SKUGTIN
MAB216804053252399664

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