MAB2170
Anti-Huntingtin Disease (HD/HTT) Antibody
CHEMICON®, mouse monoclonal, HU-4E6
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Product Name
Anti-Huntingtin Protein Antibody, a.a. 1247-1646, clone HU-4E6, ascites fluid, clone HU-4E6, Chemicon®
biological source
mouse
antibody form
ascites fluid
antibody product type
primary antibodies
clone
HU-4E6, monoclonal
species reactivity
mouse, human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HTT(3064), SLC6A4(6532)
Application
Detect Huntingtin Protein using this Anti-Huntingtin Protein Antibody, a.a. 1247-1646, clone HU-4E6 validated for use in ELISA, IP, WB, IC, IH(P).
ELISA: 1:500-1:5,000
Western blot (recombinant protein, not suitable for the natural Huntingtin) : 1:500-1:5,000
Immunohistochemistry on frozen and microwave oven treated paraffin sections (human): 1:500-1:5,000
Immunocytochemistry on transfected cells: 1:500-1:5,000
Immunoprecipitation: 1:500-1:5,000
Optimal working dilutions must be determined by the end user.
Western blot (recombinant protein, not suitable for the natural Huntingtin) : 1:500-1:5,000
Immunohistochemistry on frozen and microwave oven treated paraffin sections (human): 1:500-1:5,000
Immunocytochemistry on transfected cells: 1:500-1:5,000
Immunoprecipitation: 1:500-1:5,000
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Biochem/physiol Actions
Huntingtin Protein. No detectable cross reactivity with other proteins by Western blot.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
Epitope: a.a. 1247-1646
Huntingtin fragment from aa 1247 to 1646 as a fusion protein
Physical form
Ascites fluid. Liquid, does not contain any preservative.
Preparation Note
Maintain at -20°C in undiluted aliquots up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.
During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Anjalika Chongtham et al.
Human molecular genetics, 29(4), 674-688 (2020-01-17)
Huntington's disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates. Here we ask whether expanded polyQ is sufficient to cause
Wei Li et al.
The Journal of biological chemistry, 281(23), 15916-15922 (2006-04-06)
Huntington disease is an inherited neurodegenerative disorder that is caused by expanded CAG trinucleotide repeats, resulting in a polyglutamine stretch of >37 on the N terminus of the protein huntingtin (htt). htt is a large (347 kDa), ubiquitously expressed protein.
Baehyun Shin et al.
Molecular therapy. Nucleic acids, 11, 416-428 (2018-06-03)
The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington's disease (HD), a debilitating neurodegenerative disorder. This seemingly slight change to the primary amino acid sequence alters the physical structure of the
Passive immunization against phosphorylated tau improves features of Huntington's disease pathology.
Melanie Alpaugh et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 30(4), 1500-1522 (2022-01-21)
Huntington's disease is classically described as a neurodegenerative disorder of monogenic aetiology. The disease is characterized by an abnormal polyglutamine expansion in the huntingtin gene, which drives the toxicity of the mutated form of the protein. However, accumulation of the
Maria Masnata et al.
Acta neuropathologica, 137(6), 981-1001 (2019-02-23)
In recent years, evidence has accumulated to suggest that mutant huntingtin protein (mHTT) can spread into healthy tissue in a prion-like fashion. This theory, however, remains controversial. To fully address this concept and to understand the possible consequences of mHTT spreading
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MAB2170 | 04053252617126 |
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