MAB348A4

Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj.

Name: Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj.
Brand: MM

clone 22C11, from mouse, ALEXA FLUOR^™ 488

Synonym(s):

Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj., clone 22C11, from mouse, ALEXA FLUOR^™ 488

biological source

mouse

conjugate

ALEXA FLUOR^™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

22C11, monoclonal

species reactivity

rat, pig

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), porcine (based on 100% sequence homology), human (based on 100% sequence homology), canine (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable

isotype

IgG1

NCBI accession no.

NP_000475

UniProt accession no.

P05067

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... APP(351)

Analysis Note

Control
Mouse N1E-115 neuroblastoma cells

Evaluated by Immunocytochemistry in mouse N1E-115 neuroblastoma cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Alzheimer Precursor Protein A4 in mouse N1E-115 neuroblastoma cells.

Application

Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj. is an antibody against Alzheimer Precursor Protein A4 for use in IHC, ICC.

Immunohistochmeistry Analysis: A 1:50 dilution from a representative lot detected Alzheimer Precursor Protein A4 in adult mouse brain tissue.

Biochem/physiol Actions

Unconjugated MAB348 recognizes N-terminal amino acids 66-81 on the pre-A4 molecule (Hilbich et al., 1993). 22C11 recognizes all three isoforms of APP: immature, ~110kDa; sAPP, ~120kDa; and mature, ~130kDa (Hoffmann et al., 2000). This antibody is known to cross react with APLP2 (Slunt, 1994).

General description

Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged human and cases of Alzheimer′s Disease. The principle component of this extracellular amyloid is beta A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins is currently an active area of research.

Reacts with pre-A4. The unconjugated antibody (MAB348) recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa (Hoffmann et al., 2000).

Immunogen

Epitope: a.a. 66-81 of APP (N-terminus)

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth.

Hafsa Munir et al.

Nature communications, 12(1), 683-683 (2021-01-31)

Tumors consist of cancer cells and a network of non-cancerous stroma. Cancer-associated fibroblasts (CAF) are known to support tumorigenesis, and are emerging as immune modulators. Neutrophils release histone-bound nuclear DNA and cytotoxic granules as extracellular traps (NET). Here we show

TIMP-1 is a novel ligand of Amyloid Precursor Protein and triggers a proinflammatory phenotype in human monocytes.

Celina Eckfeld et al.

The Journal of cell biology, 222(2) (2023-01-12)

The emerging cytokine tissue inhibitor of metalloproteinases-1 (TIMP-1) correlates with the progression of inflammatory diseases, including cancer. However, the effects of TIMP-1 on immune cell activation and underlying molecular mechanisms are largely unknown. Unbiased ligand-receptor-capture-screening revealed TIMP-1-interaction with Amyloid Precursor

Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus.

Jung-Hyun Lee et al.

EBioMedicine, 77, 103903-103903 (2022-02-28)

Plasma extracellular vesicles (pEV) can harbor a diverse array of factors including active proteases and the amyloid-precursor-protein (APP) cleavage product Aβ, involved in plaque formation in Alzheimer`s diseases (AD). A potential role of such vesicles in AD pathology is unexplored.

Global Trade Item Number

SKU	GTIN
MAB348A4	04053252688898

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