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Merck

MAB4155C3

Anti-BCRP1 Antibody, clone 5D3, Cy3 conjugate

clone 5D3, from mouse, CY3 conjugate

Synonym(s):

ABC transporter, ATP-binding cassette transporter G2, ATP-binding cassette, sub-family G (WHITE), member 2, ATP-binding cassette, sub-family G, member 2, Breast cancer resistance protein, CD338 antigen, Mitoxantrone resistance-associated protein, Placent

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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biological source

mouse

conjugate

CY3 conjugate

antibody form

purified antibody

antibody product type

primary antibodies

clone

5D3, monoclonal

species reactivity

human

technique(s)

immunocytochemistry: suitable

isotype

IgG2bκ

NCBI accession no.

NP_004818

UniProt accession no.

Q9UNQ0

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... BCRP1(644079)

General description

Breast cancer resistance protein (BCRP1) is a member of the ATP-binding cassette superfamily of drug transporters thought to be involved in multi-drug resistance in human neoplastic disease. ABCG2 is expressed in drug-resistant breast, colon and gastric cancer and fibrosarcoma cancer cell lines and in blast cells from patients with acute myeloid leukemia (AML). Normal tissues that express the ABCG2 protein include placental syncytiothrophoblasts, mammary ducts and lobules, epithelium in the large intestine and colon, venous and capillary epithelium and bile canalicular membrane of the liver. Several studies indicate that ABCG2 is also expressed in stem cells of different tissues and may be useful as a stem cell marker.
72 kDa calculated

Application

Anti-BCRP1 Antibody, clone 5D3, Cy3 conjugate is an antibody against BCRP1 for use in ICC.

Analysis Note

Evaluated by Immunocytochemistry in A431 Human epidermal carcinoma cells. Immunocytochemsitry Analysis: A 1:50 dilution of this antibody detected BCRP1 in A431 Human epidermal carcinoma cells.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maria Dib et al.
Pharmacology, 108(1), 90-100 (2022-10-24)
Cisplatin is extensively used in the treatment of head and neck carcinomas. Cetuximab combination therapy is employed in recurrent and metastatic settings. Sunitinib showed positive results in the treatment of head and neck carcinomas, both as monotherapy or in combination

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