MAB5216

Anti-NMDAR2A Antibody

Name: Anti-NMDAR2A Antibody
Brand: MM

Chemicon^®, from mouse

Synonym(s):

NR2A

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-NMDAR2A Antibody, Chemicon^®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

clone

monoclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000833.2

UniProt accession no.

Q12879

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... GRIN2A(2903)

Application

Anti-NMDAR2A Antibody detects level of NMDAR2A & has been published & validated for use in IH(P), IC, IH & WB.

Immunohistochemistry (light and EM) on 4% paraformaldehyde & 0.125% glutaraldehyde fixed tissue: 2.5-5 μg/mL.

Immunocytochemistry: 2.5-5.0μg/mL

Western blot: 1-5 μg/mL Optimal working dilutions must be determined by end user.

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Amino acid region 1099-1213 from human NMDAR2A produced as a GST fusion protein.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: MAB5218

Physical form

Affinity purified immunoglobulin. Liquid in PBS. Contains no preservative.

Format: Purified

Preparation Note

Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

Andre Fischer et al.

Neuron, 48(5), 825-838 (2005-12-13)

While deregulation of cyclin-dependent kinase 5 (Cdk5) has been implicated in neurodegenerative diseases, its precise role in synaptic plasticity and memory remains elusive. Proteolytic cleavage of p35, a regulatory subunit of Cdk5, by calpain results in the generation of the

Regulation of NMDA receptors by cyclin-dependent kinase-5.

Li, BS; Sun, MK; Zhang, L; Takahashi, S; Ma, W; Vinade, L; Kulkarni, AB; Brady, RO; Pant, HC

Proceedings of the National Academy of Sciences of the USA null

Impaired Cognitive Function and Altered Hippocampal Synaptic Plasticity in Mice Lacking Dermatan Sulfotransferase Chst14/D4st1.

Qifa Li et al.

Frontiers in molecular neuroscience, 12, 26-26 (2019-03-12)

Chondroitin sulfate (CS) and dermatan sulfate (DS) proteoglycans (PGs) are major extracellular matrix (ECM) components of the central nervous system (CNS). A large body of evidence has shown that CSPGs/DSPGs play critical roles in neuronal growth, axon guidance, and plasticity

Properties and molecular identity of NMDA receptors at synaptic and non-synaptic inputs in cerebellar molecular layer interneurons.

Céline Bidoret et al.

Frontiers in synaptic neuroscience, 7, 1-1 (2015-03-10)

N-methyl-D-aspartate receptors (NMDARs) in cerebellar molecular layer interneurons (MLIs) are expressed and activated in unusual ways: at parallel fibre (PF) synapses they are only recruited by repetitive stimuli, suggesting an extrasynaptic location, whereas their activation by climbing fibre is purely

The N-methyl-D-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth.

Kim, MS; Chang, X; Nagpal, JK; Yamashita, K; Baek, JH; Dasgupta, S; Wu, G; Osada, M; Woo et al.

Oncogene null

View All Related Papers

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

Anti-NMDAR2A - Data Sheet

MOUSE ANTI-NMDAR2A

Global Trade Item Number

SKU	GTIN
MAB5216	04053252662195

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