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Key Documents

MAB7774

Sigma-Aldrich

Anti-Urokinase Antibody, NT fragment, clone 10D.7.2

clone 10D.7.2, Chemicon®, from mouse

Synonym(s):

uPA

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

10D.7.2, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NM_002658.2

UniProt accession no.

P00749

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PLAU(5328)

Immunogen

Amino Terminal Fragment of uPA
Epitope: N-terminus fragment

Application

Research Category
Metabolism
Research Sub Category
Enzymes & Biochemistry
This Anti-Urokinase Antibody, N-terminus fragment, clone 10D.7.2 is validated for use in ELISA, WB for the detection of Urokinase.
Western blot: 1:1000-1:3000

ELISA

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Urokinase Plasminogen Acitivator is a serine protease (SERPIN) that converts plasminogen into the active protease plasmin. uPA is secreted from cells in as the inactive 52 kDa single chain precursor which is activated into the two chain form consisting of an alpha and beta chain.MAB7774 is specific for Human uPA, other species not tested.

Physical form

Format: Purified
Purified immunoglobulin. Liquid in 0.02 M phosphate buffer containing 0.25 M NaCl2 and 0.1% NaN3.

Preparation Note

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB776

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Falgun Shah et al.
Cell chemical biology, 24(7), 858-869 (2017-07-04)
Cutaneous reactions represent one of the most common adverse drug effects observed in clinical trials leading to substantial compound attrition. Three negative allosteric modulators (NAMs) of metabotropic glutamate receptors (mGluRs), which represent an important target for neurological diseases, developed by

Global Trade Item Number

SKUGTIN
MAB777404053252501609

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