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MABC287

Anti-PXR Antibody, clone 1F10.1

Name: Anti-PXR Antibody, clone 1F10.1
Brand: MM

clone 1F10.1, from mouse

Synonym(s):

Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X receptor, Steroid and xenobiotic receptor, SXR, PXR

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

1F10.1, monoclonal

Application:

Citations:

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Properties

biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1F10.1, monoclonal

species reactivity

human

species reactivity (predicted by homology)

chimpanzee (based on 100% sequence homology), gorilla (based on 100% sequence homology)

technique(s)

western blot: suitable

isotype

IgG2bκ

NCBI accession no.

NP_003880

UniProt accession no.

O75469

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... NR1I2(8856)

Description

General description

Nuclear receptor subfamily 1 group I member 2 (UniProt O75469; also known as Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X nuclear receptor, Steroid and xenobiotic receptor, SXR) is encoded by the NR1I2 (also known as BXR, PAR, PRR, PXR, SAR, SXR, ONR1) gene (Gene ID 8856) in human. Pregnane X receptor (PXR) is a nuclear receptor that displays similarity to PPAR and RXR. PXR is activated by a large number of endogenous and exogenous chemicals including steroids and antibiotics. One of the key roles of PXR is the induction of CYP3A4, a P450 enzyme involved in drug metabolism.

~53 kDa observed. Uniprot describes 7 isoforms produced by alternative splicing ranging from ~40 kDa-54 kDa

Immunogen

KLH-conjugated linear peptide corresponding to human PXR.

Application

Detect PXR using this Anti-PXR Antibody, clone 1F10.1 validated for use in Western Blotting.

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected PXR in 10 µg of human liver tissue lysate.

Biochem/physiol Actions

Epitope is present in all 7 alternative spliced isoforms (isoform 1A/PRR1-A, 1B/PRR1-B, 1C/PRR1-C, 2A/PRR2-A, 2B/PRR2-V, 2C/PRR2-C, and isoform 3).

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blotting in human colon tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PXR in 10 µg of human colon tissue lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c