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Merck

MABD55

Anti-TERT (human) Antibody, clone 2C4

clone 2C4, from mouse

Synonym(s):

Telomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, Short name=TP2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2C4, monoclonal
Application:
ICC, IP, WB
Citations:
1

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2C4, monoclonal

species reactivity

human

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgMκ

NCBI accession no.

NP_001180305

UniProt accession no.

O14746

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TERT(7015)

General description

Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the telomerase. It is also responsible for addition of TTAGGG repeats to the telomere ends of the chromosome, which is important in maintaining cell immortality. In most normal human cells the expression of hTERT is very low. On the other hand, greater than 90 % of human tumors of different pathology and origins have been shown to upregulate telomerase expression, making hTERT a cancer-associated target.
~90 kDa observed.
Three isoforms exist for human TERT: Isoform 1 at 127 kDa, Isoform 2 at 90 kDa, and Isoform 3 at 120 kDa

Immunogen

Full length recombinant protein corresponding to human TERT.

Application

Anti-TERT (human) Antibody, clone 2C4 is an antibody against TERT (human) for use in WB, IC & IP.
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to detect TERT in HeLa cells (Masutomi, K., et al. (2003). Cell, Vol. 114:241–253).

Immunocytochemistry Analysis: A representative lot was used by an independent laboratory to detect TERT in HeLa cells, BJ and WI-38 fibroblasts (Masutomi, K., et al. (2003). Cell, Vol. 114:241–253).

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in human lymph node tissue lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected TERT in 10 µg of human lymph node tissue lysate.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Andrew T Meram et al.
Anticancer research, 38(7), 3843-3852 (2018-07-05)
Hydrogen sulfide (H2S) and the enzymes that synthesize it, cystathionine-b-synthase, cystathionine γ-lyase, and 3-mercaptopyruvate, are increased in different human malignancies. Due to its short half-life, H2S concentrations have not been directly measured in a human malignancy. Here we directly measured

Global Trade Item Number

SKUGTIN
MABD5504053252419591

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