MABE951

Anti-Histone H3.3 (H3-3A,H3-3B) Antibody

Name: Anti-Histone H3.3 (H3-3A,H3-3B) Antibody
Brand: MM

rat monoclonal, 6C4A3

Synonym(s):

Histone H3.3, H3.3A, H3F3

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

Product Name

Anti-Histone H3.3 Antibody, clone 6C4A3, clone 6C4A3, 1 mg/mL, from rat

biological source

rat

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6C4A3, monoclonal

species reactivity

human, monkey, mouse, canine

concentration

1 mg/mL

technique(s)

western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_002098

UniProt accession no.

P84243

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... H3F3B(3021)

Analysis Note

Evaluated by Western Blotting in HeLa acid extract.

Western Blotting Analysis: 1 µg/mL of this antibody detected Histone H3.3 in 10 µg of HeLa acid extract.

Application

Anti-Histone H3.3 Antibody, clone 6C4A3 is an antibody against Histone H3.3 for use in western blotting.

Western Blotting Analysis: 0.1 µg/mL from a representative lot detected Histone H3.3 with recombinant H3.3 proteins. Additionally, 1 µg/mL from a representative lot detected Histone H3.3 in HeLa, COS1, NIH/3T3, NRK, and MDCK whole cell lysates (Prof. Taro Tachibana, Cell Engineering Corporation.).

General description

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

~17 kDa observed

Physical form

Format: Purified

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs.

Zhexin Zhu et al.

Cell stem cell, 20(2), 274-289 (2016-12-13)

The chromatin landscape and cellular metabolism both contribute to cell fate determination, but their interplay remains poorly understood. Using genome-wide siRNA screening, we have identified prohibitin (PHB) as an essential factor in self-renewal of human embryonic stem cells (hESCs). Mechanistically, PHB

Global Trade Item Number

SKU	GTIN
MABE951	04053252970603

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