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Merck

MABF41

Anti-Interleukin-6 (IL-6) Antibody, clone 1G3

clone AB42_51.38C8.1G3, from mouse

Synonym(s):

interleukin 6 (interferon, beta 2), IFN-beta-2, B-cell stimulatory factor 2, interleukin-6, Interferon beta-2, B cell stimulatory factor-2, Hybridoma growth factor, B-cell differentiation factor, CTL differentiation factor, interleukin BSF-2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-Interleukin-6 (IL-6) Antibody, clone 1G3, clone AB42_51.38C8.1G3, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

clone

AB42_51.38C8.1G3, monoclonal

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG2bκ

NCBI accession no.

NP_000591

UniProt accession no.

P05231

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Analysis Note

Control
Human IL-6 recombinant protein
Evaluated by Western Blot with human IL-6 recombinant protein.

Western Blot Analysis: 0.5 g/mL of this antibody detected 10 g of human IL-6 recombinant protein.

Application

Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 is an antibody against Interleukin-6 (IL-6) for use in WB.
Research Category
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Interleukin-6 (IL-6) is a pro-inflammatory cytokine that seems to be involved in the late stages of CTL generation. Other biological functions also include amplification and the inflammatory response. Combination therapies including IL-6 have been shown to have positive effects on specific malignant tumor types. The accumulation of IL-6 in the CNS is usually detrimental and can contribute to pathology of CNS diseases. IL-6 signaling is negatively regulated by TGF-beta, which down regulates STAT1, STAT3 and ICAM-1 expression. IL-6 expression has been linked to inflammatory bowel disease (IBD) and is also the primary clinical target for IBD. Clinical use of an antibody for the IL-6 receptor (IL-6R) has been promising in treating rheumatoid arthritis, systemic juvenile idiopathic arthritis and Castleman’s disease.
~21 kDa observed

Immunogen

Human IL-6 fused to the soluble domain of the IL-6R.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 04-1095

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xiaoli Zhou et al.
Journal of the American Society of Nephrology : JASN, 27(6), 1765-1776 (2015-10-17)
Deficiency of the antiaging gene Klotho (KL) induces renal damage and hypertension through unknown mechanisms. In this study, we assessed whether KL regulates expression of CYP11B2, a key rate-limiting enzyme in aldosterone synthesis, in adrenal glands. We found that haplodeficiency
Yan Wang et al.
Experimental and therapeutic medicine, 15(3), 2830-2836 (2018-02-20)
The natural iso-flavonoid, biochanin A, is categorized as a phytoestrogen and has been demonstrated to exhibit various pharmacological properties. However, no effects of biochanin A on lung cancer cell lines have been reported. Therefore, the present study aimed to demonstrate

Global Trade Item Number

SKUGTIN
MABF4104053252422522

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