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Merck

MABN18

Anti-PINK1 Antibody, clone N4/49

clone N4/49, from mouse

Synonym(s):

PTEN induced putative kinase 1, protein kinase BRPK, serine/threonine-protein kinase PINK1, PTEN-induced putative kinase protein 1, Parkinson disease (autosomal recessive) 6

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
N4/49, monoclonal
Application:
IHC, WB
Citations:
-

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

N4/49, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable, western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_115785

UniProt accession no.

Q9BXM7

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PINK1(65018)

General description

Mutations in the PTEN-induced kinase 1 (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.
63 kDa Observed

Application

This Anti-PINK1 Antibody, clone N4/49 is validated for use in IH, WB for the detection of PINK1.
Western Blot Analysis: A previous lot of MABN18 recognized PINK1 in HEK cells and a rat brain LSP, as reported by an independent laboratory (UC Davis/NIH NeuroMab Facility; www.neuromab.org/neuromab@ucdavis.edu).

Biochem/physiol Actions

This antibody recognizes PINK1.

Physical form

Format: Purified

Analysis Note

Control
Human normal brain tissue
Evaluated by Immunohistochemistry in human normal brain tissue.

Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected PINK1 in human normal brain tissue.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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