MABN677
Anti-ADNP1 Antibody, clone 5F5.1
clone 5F5.1, from mouse
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
5F5.1, monoclonal
Application:
WB
Citations:
-
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
5F5.1, monoclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ADNP(23394)
General description
ADNP1, also known as Activity-dependent neuroprotector homeobox protein, and encoded by the gene ADNP/ADNP1/KIAA0784, is a potential transcription factor that appears to mediate some of the neuroprotective peptide VIP associated effects involving normal growth and cancer proliferation. ADNP1 is widely expressed and localized to the nucleus. ADNP1 is strongly expressed in heart and skeletal muscle tissue and the brain. ADNP1 is also found expressed in colon and breast cancer tissues but not in normal tissues, thus ADNP1 can be used as a potential cancer marker in some tissues. ADNP1 is upregulated in normal proliferative tissues by VIP, and it may increase the viability of certain cell types through the modulation of p53 activity. Interestingly, new research shows that ADNP1 may be a potential biomarker for Alzheimer’s disease, where ADP1 expression was specifically down-regulated in AD patients.
~145 kDa observed
Immunogen
Epitope: Near C-terminus
GST-tagged recombinant protein corresponding to human ADNP1, near the C-terminus.
Application
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
This Anti-ADNP1 Antibody, clone 5F5.1 is validated for use in Western Blotting for the detection of ADNP1.
Physical form
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in SH-SY-5Y cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected ADNP1 in 200 µg of SH-SY-5Y cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected ADNP1 in 200 µg of SH-SY-5Y cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| MABN677 | 04053252978869 |
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