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MABN68

Sigma-Aldrich

Anti-DLG4 Antibody

mouse monoclonal, K28/43

Synonym(s):

Postsynaptic density protein 95, Synapse-associated protein 90, Tax interaction protein 15, discs large homolog 4, discs, large homolog 4 (Drosophila), post-synaptic density protein 95

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Product Name

Anti-PSD95 Antibody, clone K28/43, clone K28/43, from mouse

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

K28/43, monoclonal

species reactivity

rat

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), human (immunogen homology)

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_001356

UniProt accession no.

P78352

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... DLG4(1742)

General description

PSD95 (postsynaptic density 95) represent a class of anchoring proteins which serve to localize various neuronal ion channels to post-synaptic densities. PSD95 and related proteins contain PDZ domains, which interact with NMDA receptors and voltage-gated K+ channels via a ET/SXV motif in the cytoplasmic carboxyl terminus of the receptor channels.
~95 kDa observed.

Immunogen

Recombinant protein corresponding to human PSD95.

Application

Detect PSD95 using this Anti-PSD95 Antibody, clone K28/43 validated for use in IH, WB & IC.
Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected PSD95 in rat cortex tissue.

Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC. (Maeda, T., et al. (2005). Invest. Ophthalmol. Vis. Sci. 46(11):4320-4327.)
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Rat brain tissue lysate
Evaluated by Western Blot in rat brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected PSD95 on 10 µg of rat brain tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 04-1066

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lu Yang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(48), 10846-10857 (2004-12-03)
The specification and organization of glutamatergic synaptic transmission require the coordinated interaction among glutamate receptors and their synaptic adaptor proteins closely assembled in the postsynaptic density (PSD). Here we investigated the interaction between NMDA receptors and metabotropic glutamate receptor 5
Vibeke M Bruinenberg et al.
Nutrients, 8(4), 185-185 (2016-04-23)
The inherited metabolic disease phenylketonuria (PKU) is characterized by increased concentrations of phenylalanine in the blood and brain, and as a consequence neurotransmitter metabolism, white matter, and synapse functioning are affected. A specific nutrient combination (SNC) has been shown to
Keisuke Handa et al.
Journal of virology, 81(3), 1379-1389 (2006-11-24)
In most cervical cancers, DNAs of high-risk mucosotropic human papillomaviruses (HPVs), such as types 16 and 18, are maintained so as to express two viral proteins, E6 and E7, suggesting that they play important roles in carcinogenesis. The carboxy-terminal PDZ
Maria Eriksson et al.
Biochemical and biophysical research communications, 361(1), 127-132 (2007-07-31)
When screening a brain cDNA library, we found that the N-methyl-D-aspartate receptor subunit NR3A binds to microtubule-associated protein (MAP) 1S/chromosome 19 open reading frame 5 (C19ORF5). The interaction was confirmed in vitro and in vivo, and binding of MAP1S was
Optimized protocol for retinal wholemount preparation for imaging and immunohistochemistry.
Ivanova, E; Toychiev, AH; Yee, CW; Sagdullaev, BT
Journal of Visualized Experiments null
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Global Trade Item Number

SKUGTIN
MABN6804053252414237

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