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Merck

62862

Sodium dodecyl sulfate

greener alternative

≥90% ((Assay))

Synonym(s):

Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt, SDS, Sodium lauryl sulfate

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About This Item

Linear Formula:
CH3(CH2)11OSO3Na
CAS Number:
151-21-3
Molecular Weight:
288.38
NACRES:
NA.21
PubChem Substance ID:
57651912
eCl@ss:
39093306
UNSPSC Code:
12161900
EC Number:
205-788-1
MDL number:
MFCD00036175
Beilstein/REAXYS Number:
3599286

Product Name

Sodium dodecyl sulfate, ≥90% ((Assay))

InChI key

DBMJMQXJHONAFJ-UHFFFAOYSA-M

InChI

1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

SMILES string

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

description

anionic
 62

assay

≥90% ((Assay))

form

(Rods)

mol wt

288.38 g/mol

Quality Level

100

greener alternative product characteristics

Catalysis
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technique(s)

LC/MS: suitable
electrophoresis: suitable
protein quantification: suitable

mp

204-207 °C (lit.)

solubility

water: soluble

density

(1.03 g/cm3 at 20 °C (68 °F))

HLB

40

application(s)

(Western Blot)

greener alternative category

Aligned

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Application

Anionic detergent
Sodium dodecyl sulfate has been used:

  • to prepare Chit for coating the Janus micromotors for the synthesis of magnesium (Mg)-based micromotors
  • as a component in low salt lysis buffer to lyse the edible bird’s nest (EBN) treated cells for western blot analysis
  • in the preparation of decellularizing solution to scale down and decellularize skin fragments

Biochem/physiol Actions

Sodium dodecyl sulfate (SDS) is frequently used as an ingredient in a wide range of products, including pharmaceuticals, and product formulations. It is broadly used in several applications including electrophoresis for the separation of proteins and as an organic template for preparing periodic mesoporous organosilica nanospheres. SDS is also used in the solubilization of proteins and lipids, as well as drugs, dispersion of functionalized carbon nanotubes and graphene sheets, and gas hydrate formation. It is commonly used for the quick disruption of biological membranes. Due to its ability to disrupt the tissue architecture, SDS is preferred in several nucleic acid purification reagents. SDS has very low solubility in high salt, and chaotropic solutions and is readily precipitable in the presence of potassium salts, so it is usually not added to guanidinium buffers.

Features and Benefits

  • Assay: ≥90%
  • Suitable for LC/MS, electrophoresis, and protein quantification
  • Inhibits RNase and deoxyribonuclease (DNase) activity

General description

Sodium dodecyl sulfate (SDS), also known as sodium lauryl sulfate (SLS), has an alkyl tail of 12 carbon atoms attached to a sulfate group. It is an anionic surfactant due to the negative charge of its sulfate group.
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Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Flam. Sol. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

4.1B - Flammable solid hazardous materials

wgk

WGK 2

flash_point_f

338.0 °F

flash_point_c

170 °C

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB3907
SDBB2484
STBL4367
STBL3314
STBL2722

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Decellularization for the Preparation of Highly Preserved Human Acellular Skin Matrix for Regenerative Medicine
Romano V, et al.
Journal of Visualized Experiments (2021)
Resilient Ribonucleases
Farrell RE
RNA Methodologies, 155-172 (2010)
A Novel Hydrate Form of Sodium Dodecyl Sulfate and Its Crystallization Process
Lee HL, et al.
ACS Omega (2021)
Berta Esteban-Fernández de Ávila et al.
Nature communications, 8(1), 272-272 (2017-08-18)
Advances in bioinspired design principles and nanomaterials have led to tremendous progress in autonomously moving synthetic nano/micromotors with diverse functionalities in different environments. However, a significant gap remains in moving nano/micromotors from test tubes to living organisms for treating diseases
Queenie Wing Sze Lai et al.
Frontiers in pharmacology, 12, 685982-685982 (2021-08-07)
Edible bird's nest (EBN) has been consumed as a Chinese delicacy for hundreds of years; the functions of which have been proposed to prevent lung disease, strengthen immune response, and restore skin youthfulness. To support the skin function of EBN
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