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30970

Sodium deoxycholate

Name: Sodium deoxycholate
Brand: SIGMA

BioXtra, ≥98.0% (dry matter, NT)

Synonym(s):

3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₉NaO₄

CAS Number:

302-95-4

Molecular Weight:

414.55

UNSPSC Code:

12161900

NACRES:

NA.21

PubChem Substance ID:

57648497

EC Number:

206-132-7

Beilstein/REAXYS Number:

3581950

MDL number:

MFCD00064139

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Properties

biological source

ox bile

Quality Segment

300

description

anionic

product line

BioXtra

assay

≥98.0% (dry matter, NT)

form

powder

optical activity

[α]20/D +44±2°, c = 2% in H₂O

mol wt

micellar avg mol wt 1200-5000

aggregation number

3-12

technique(s)

DNA purification: suitable, RNA purification: suitable, electrophoresis: suitable

impurities

≤1% cholic acid (HPLC), ≤6% water

CMC

2-6 mM (20-25°C)

solubility

water: soluble 1 gm in 10 ml, clear, colorless to very faintly yellow

cation traces

Ca: ≤500 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤10 mg/kg, Mg: ≤10 mg/kg, Mn: ≤5 mg/kg, Ni: ≤5 mg/kg, Pb: ≤10 mg/kg, Zn: ≤5 mg/kg

HLB

application(s)

advanced drug delivery

functional group

carboxylic acid

SMILES string

[Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

InChI key

FHHPUSMSKHSNKW-SMOYURAASA-M

Description

General description

Sodium Deoxycholate, a bile acid derivative, is a crucial component in biochemical and cell biology research. This water-soluble detergent is widely used in protein-related experiments, including cell lysates and liposome preparation. It aids in membrane protein extraction, lipid compound extraction, and cell nucleus separation. Sodium Deoxycholate is also applied in cholesterol flocculation tests and affinity chromatography for column elution or regeneration. It is commonly used in microbiology for cell lysing, especially because it can be removed from the solution via dialysis.

Sodium Deoxycholate is also utilized in eluting buffers for affinity chromatography and plays a crucial role in DNA and RNA extraction from cells and tissues in molecular biology applications. Additionally, it is used as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Application

Sodium deoxycholate has been used for preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Biochem/physiol Actions

Sodium deoxycholate is a bile salt that stimulates the apical to basolateral accumulation of epirubicin in Caco-2 cells as well as increased serosal absorption of epirubicin in the rat jejunum and ileum. Sodium deoxycholate dissociates histones II from DNA as well as causes lysis of the viral membrane.

Features and Benefits

Suitable for Cell Biology and Biochemical Research
Can be used in Electrophoresis, DNA and RNA purification
Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications.
High purity product for research applications

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)