A4284

L-Asparagine monohydrate

Name: <SC>L</SC>-Asparagine monohydrate
Brand: SIGMA

BioReagent, suitable for cell culture

Synonym(s):

(S)-(+)-2-Aminosuccinamic acid, (S)-2-Aminosuccinic acid 4-amide, L-Aspartic acid 4-amide

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All Photos(4)

About This Item

Linear Formula:

NH₂COCH₂CH(NH₂)COOH · H₂O

CAS Number:

5794-13-8

Molecular Weight:

150.13

UNSPSC Code:

12352209

NACRES:

NA.75

PubChem Substance ID:

24890843

EC Number:

200-735-9

Beilstein/REAXYS Number:

1723527

MDL number:

MFCD00151038

Product Name

L-Asparagine monohydrate, BioReagent, suitable for cell culture

InChI key

RBMGJIZCEWRQES-DKWTVANSSA-N

InChI

1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1

SMILES string

[H]O[H].N[C@@H](CC(N)=O)C(O)=O

biological source

synthetic

product line

BioReagent

assay

≥99% (TLC)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white to off-white

mp

233-235 °C (lit.)

Quality Level

300

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Related Categories

Amino Acids

Biochemicals

Cell Culture Supplements & Reagents

Application

L-Asparagine monohydrate has been used:

as a media supplement to culture Black Mexican Sweet (BMS) cells
to prepare Adams III media to supplement C+Y medium for culturing Streptococcus pneumoniae
in an asparagine-rich diet to study the E0771 syngeneic breast tumor growth and survival in mice

Biochem/physiol Actions

L-Asparagine (L-Asp) is a nonessential amino acid involved in the synthesis of critical cellular proteins of human cells. It is synthesized from oxaloacetic acid. L-Asp is used as a growth supplement for tumor cells in in vitro conditions.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Plasma membrane (PM) intrinsic proteins (PIPs) are aquaporins facilitating the diffusion of water and small solutes. The functional importance of the PM organisation of PIPs in the interaction with other cellular structures is not completely understood. We performed a pull-down

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.

Abigail S Krall et al.

Cell metabolism, 33(5), 1013-1026 (2021-02-21)

Mitochondrial respiration is critical for cell proliferation. In addition to producing ATP, respiration generates biosynthetic precursors, such as aspartate, an essential substrate for nucleotide synthesis. Here, we show that in addition to depleting intracellular aspartate, electron transport chain (ETC) inhibition

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