C7039

Cefotaxime sodium salt

Name: Cefotaxime sodium salt
Brand: SIGMA

powder or crystals, suitable for plant cell culture, BioReagent

Synonym(s):

Cefotaxim sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₆N₅NaO₇S₂

CAS Number:

64485-93-4

Molecular Weight:

477.45

NACRES:

NA.72

PubChem Substance ID:

24892923

UNSPSC Code:

10171502

EC Number:

264-915-9

MDL number:

MFCD00079073

Beilstein/REAXYS Number:

5711411

Product Name

Cefotaxime sodium salt, suitable for plant cell culture, BioReagent, powder or crystals

InChI key

AZZMGZXNTDTSME-JUZDKLSSSA-M

InChI

1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

SMILES string

[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O

product line

BioReagent

form

powder or crystals

technique(s)

cell culture | plant: suitable

color

off-white to pale yellow

solubility

H₂O: 10% ( )

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

application(s)

agriculture

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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Related Categories

Cell Culture & Analysis

Cell Culture Media & Buffers

Cell Culture Supplements & Reagents

Molecular Biology & Functional Genomics

Plant Culture Media

Application

Cefotaxime sodium salt has been used as an test antibiotic in antibiotic susceptibility testing (AST) methods. It has also been used as an antibiotic to remove bacteria from O. tauri cultures.

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

Cefotaxime, a cephalosporin antibiotic, is active against both gram-negative and gram-positive bacteria. In addition, cefotaxime blocks the division of cyanobacteria. It also has an ability to inhibit the cell division of lower plant organelles/plastids such as the photosynthetic organelles of glaucophytes and chloroplasts of bryophytes.

Mode of Action: Inhibits bacterial cell wall synthesis.

General description

Chemical structure: ß-lactam

Other Notes

Broad spectrum third generation cephalosporin antibiotic.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Keep in a dry place.

pictograms

GHS08

signalword

Danger

hcodes

H317,H334

pcodes

P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Cefotaxime. A review of its antibacterial activity, pharmacological properties and therapeutic use.

AA C, et al.

Drugs (1983)

Bacterial nanoscale cultures for phenotypic multiplexed antibiotic susceptibility testing

Weibull E, et al.

Journal of Clinical Microbiology, 52(9), 3310-3317 (2014)

Metabolic profiling identifies trehalose as an abundant and diurnally fluctuating metabolite in the microalga Ostreococcus tauri

Hirth M, et al.

Metabolomics, 13(9), 68-68 (2017)

Antibiogram and beta-lactamase genes among cefotaxime resistant E. coli from wastewater treatment plant.

Anthony Ayodeji Adegoke et al.

Antimicrobial resistance and infection control, 9(1), 46-46 (2020-03-14)

The World Health Organization (WHO) recently classified Enterobacteriaceae resistance to third-generation cephalosporin into the group of pathogens with critical criteria for future research. A study to assess the antibiogram and beta-lactamase genes among the cefotaxime resistant E. coli (CREc) from

Urinary Tract Infection in Children and Antimicrobial Resistance Pattern: Children UTI and Antibiotic Resistance (2019)

View All Related Papers

Protocols

Antibiotics in Plant Tissue Culture Protocol

Reference guide and preparation guide for antibiotic and antimycotic use in plant tissue culture.