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Adenosine 5′-triphosphate (ATP) disodium salt hydrate

Name: Adenosine 5′-triphosphate (ATP) disodium salt hydrate
Brand: SIGMA

≥90%, bacterial (Corynebacterium sp), lyophilized powder

Synonym(s):

ATP disodium hydrate

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About This Item

Linear Formula:

C₁₀H₁₄N₅O₁₃P₃Na₂ · xH₂O

CAS Number:

34369-07-8

Molecular Weight:

551.14 (anhydrous basis)

UNSPSC Code:

12352202

eCl@ss:

32160414

PubChem Substance ID:

24895005

NACRES:

NA.26

EC Number:

213-579-1

MDL number:

MFCD00150755

Product Name

Adenosine 5′-triphosphate (ATP) disodium salt hydrate, vial of ~1 mg ATP

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

biological source

bacterial (Corynebacterium sp)

assay

≥90%

form

lyophilized powder

packaging

vial of ~1 mg ATP

solubility

water: soluble, clear, colorless (1 vial + 0.1 mL)

storage temp.

−20°C

Quality Level

200

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Related Categories

Phosphates

Proteins & Enzymes

Detection Substrates & Enzymes

Application

Adenosine 5′-triphosphate (ATP) disodium salt hydrate has been:

used as a standard to measure ATP by bioluminescence method
used in kinase buffer to assess the interaction between death-associated protein kinases (DAPK2) and 14-3-3-β
used as a standard in ATP colorimetric assay

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is one of the nucleoside triphosphate present in living system. It controls various biologic processes such as glucose metabolism, muscle contraction and neurotransmission. Apart from this, ATP serves as an important energy source for the cell. Administration of ATP might be useful in the treatment of non-small-cell lung cancer.

Adenosine 5′-triphosphate was shown to have inhibitory effects on the inflammatory response by abrogating secretion of TNF-α and promoting secretion of Interleukin-10.

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems

Preparation Note

Each vial contains ~1.2 mg of Na₂ATP • 3H₂O equivalent to ~1.0 mg of ATP (2.0 μmol). Actual amount printed on the label.

Prepared to be substantially vanadium-free.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia--ischemia

Chavez-Valdez R, et al.

Neuroscience, 219, 192-203 (2012)

Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood.

Els L R Swennen et al.

European journal of immunology, 35(3), 852-858 (2005-02-19)

In vitro studies suggest that extracellular nucleotides and nucleosides may be important regulators of inflammatory and immune responses. Most studies with adenosine 5'-triphosphate (ATP) have been performed in cell lines, which are remote from the human situation. The purpose of

Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.

Shay Eliahu et al.

Journal of medicinal chemistry, 53(24), 8485-8497 (2010-11-26)

Nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyze extracellular nucleotides and dinucleotides and thus control purinergic signaling. Enhanced NPP activity is implicated in health disorders such as osteoarthritis and cancer. We designed novel diadenosine polyphosphonate derivatives as potential NPP inhibitors. Analogues 1-4 bear a

Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.

Andrei A Ivanov et al.

Journal of medicinal chemistry, 50(6), 1166-1176 (2007-02-17)

A rhodopsin-based homology model of the nucleotide-activated human P2Y2 receptor, including loops, termini, and phospholipids, was optimized with the Monte Carlo multiple minimum conformational search routine. Docked uridine 5'-triphosphate (UTP) formed a nucleobase pi-pi complex with conserved Phe3.32. Selectivity-enhancing 2'-amino-2'-deoxy

Identification of novel death-associated protein kinase 2 interaction partners by proteomic screening coupled with bimolecular fluorescence complementation

Geering B, et al.

Molecular and Cellular Biology, 36(1), 132-143 (2016)

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