G8415

L-Glutamic acid

Name: <SC>L</SC>-Glutamic acid
Brand: SIGMA

98.5-100.5%, suitable for cell culture, non-animal source, meets EP testing specifications

Synonym(s):

(S)-2-Aminopentanedioic acid, Glu

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About This Item

Linear Formula:

HO₂CCH₂CH₂CH(NH₂)CO₂H

CAS Number:

56-86-0

Molecular Weight:

147.13

PubChem Substance ID:

24895340

eCl@ss:

32160406

UNSPSC Code:

12352209

NACRES:

NA.26

EC Number:

200-293-7

MDL number:

MFCD00002634

Beilstein/REAXYS Number:

1723801

Product Name

L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

biological source

non-animal source

agency

meets EP testing specifications

assay

98.5-100.5%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

205 °C (dec.) (lit.)

solubility

1 M HCl: 100 mg/mL

density

1.54 g/cm³ at 20 °C

anion traces

chloride (Cl^-): ≤200 ppm
sulfate (SO₄^2-): ≤200 ppm

cation traces

As: ≤1 ppm, passes test
Fe: ≤10 ppm, passes test
NH₄⁺: ≤200 ppm, passes test

application(s)

pharmaceutical (small molecule)

Quality Level

300

Gene Information

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Related Categories

Amino Acids

Biochemicals

Cell Culture Supplements & Reagents

Application

L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line.

Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase. Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Differential Effect of Culture Temperature and Specific Growth Rate on CHO Cell Behavior in Chemostat Culture

Vergara M9

PLoS ONE, 9(4) (2001)

Geometric effect of cell adhesive polygonal micropatterns on neuritogenesis and axon
guidance

Min Jee Jang and Yoonkey Nam

Journal of Neural Engineering (2012)

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

Cell Metabolism, 11-20 (2008)

Aqueous micro-contact printing of cell-adhesive biomolecules for patterning neuronal cell cultures.

Jang MJ, et al.

BioChip Journal, 6(2), 107-113 (2012)

Glutamic Acid, Twenty Years Later

S. Garattini

The Journal of Nutrition, 130(4), 901S-909S (2000)

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Articles

Glutamine Metabolism in Cancer Cells

Sigma article discusses tumor cell metabolic pathways, focusing on aerobic glycolysis and mitochondrial activity.

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