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Merck

MAK112

Arginase Activity Assay Kit

sufficient for 200 colorimetric tests

Synonym(s):

Arginase Test Kit

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About This Item

NACRES:
NA.84
UNSPSC Code:
12161503

Key Documents

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usage

sufficient for 200 colorimetric tests

detection method

colorimetric

relevant disease(s)

cancer; immunological diseases; gastrointestinal diseases

storage temp.

−20°C

Gene Information

human ... ARG1(383), ARG2(384)
mouse ... ARG1(11846), ARG2(11847)
rat ... ARG2(29215), Arg1(29221)

Related Categories

General description

Arginase is a manganese-containing enzyme that catalyzes the conversion of arginine to urea and ornithine. Two isoforms of arginase are present in most mammals which differ in their tissue distribution and subcellular localization. Arginase I is a cytoplasmic protein predominantly expressed in the liver where it catalyzes the fifth and final step of the Urea Cycle. Arginase II is a mitochondrial protein with broader tissue distribution whose function may include nitric oxide and polyamine metabolism. Decreased activity or expression of Arginase I results in the autosomal recessive disorder hyperarginemia. Increased serum Arginase activity is implicated in hepatic injury and in certain pathological conditions such as cancer. Arginase also participates in multiple inflammatory reactions in the immune system, such as macrophage-mediated cytotoxicity.

Application

Arginase Activity Assay Kit has been used to assess the activity of arginase.
Suitable for the detection of arginase activity in enzyme preparations, serum, plasma, tissue culture, and similar samples. Suitable for studying the effects of drugs on arginase activity.

Biochem/physiol Actions

In this assay, arginase catalyzes the conversion of arginine to urea and ornithine. The urea produced specifically reacts with the substrate to generate a colored product, proportional to the arginase activity present.

Features and Benefits

Compatible with high-throughput handling systems.

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1A

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 2

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Certificates of Analysis (COA)

Lot/Batch Number
112CF06A24
112CF06A24
112CF05A19
112CE06A26
112CE06A19

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Yuxin Shu et al.
Immunology, 160(4), 345-356 (2020-04-21)
Macrophages are particularly abundant and play an important role throughout the tumor progression process, namely, tumor-associated macrophages (TAM) in the tumor microenvironment. TAM can be polarized to disparate functional phenotypes, the M1 and M2 macrophages. M1-like type macrophages are defined
Anti-apoptotic role of spermine against lead and/or gamma irradiation-induced hepatotoxicity in male rats.
Rasha A K, et al.
Environmental Science and Pollution Research International, 24(31), 24272-24283 (2017)
Andrew F Cumpstey et al.
Nitric oxide : biology and chemistry, 94, 27-35 (2019-10-12)
Native highlanders (e.g. Sherpa) demonstrate remarkable hypoxic tolerance, possibly secondary to higher levels of circulating nitric oxide (NO) and increased microcirculatory blood flow. As part of the Xtreme Alps study (a randomised placebo-controlled trial of dietary nitrate supplementation under field
Monica Vaccari et al.
Frontiers in immunology, 10, 1072-1072 (2019-05-30)
Vaccination with DNA-SIV + ALVAC-SIV + gp120 alum results in inflammasome activation, high levels of IL-1β production, emergency myelopoiesis, and the egress of CXCR4+ CD14+ pre-monocytes from bone marrow. Previously we have shown that this vaccine-induced innate monocyte memory is
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
Martina H.
Journal of inherited metabolic disease, 39(3), 331?340-331?340 (2016)
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Product Information Sheet - MAK112

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