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R103

Ritanserin

powder

Synonym(s):

6-[2-[4-(bis(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

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About This Item

Empirical Formula (Hill Notation):
C27H25F2N3OS
CAS Number:
87051-43-2
Molecular Weight:
477.57
NACRES:
NA.77
PubChem Substance ID:
24278117
UNSPSC Code:
12352200
MDL number:
MFCD00069341
Form:
powder
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form

powder

Quality Segment

200

color

white

solubility

methanol: >10 mg/mL, DMSO: >10.1 mg/mL, 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble, dilute aqueous base: insoluble

SMILES string

CC1=C(CCN2CCC(\CC2)=C(\c3ccc(F)cc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1

InChI

1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3

InChI key

JUQLTPCYUFPYKE-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356)
rat ... Adra1a(29412), Drd2(24318), Htr1a(24473), Htr2a(29595), Htr7(65032)

Application

Ritanserin has been used in behavioral testing and as a serotonin 2A receptor (5-HT2A)-receptor antagonist.

Biochem/physiol Actions

Ritanserin is a potent serotonin 2A receptor (5-HT2A) serotonin receptor antagonist/inverse agonist, which crosses the blood-brain barrier. It modulates 5-HT2A receptors and has been suggested to have antiparkinsonian effect. Ritanserin also impacts schizophrenia by modulating mood, cognition and negative symptoms.
Potent 5-HT2A serotonin receptor antagonist/inverse agonist that crosses the blood-brain barrier.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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