32402
Sulfaguanidine
VETRANAL®, analytical standard
Synonym(s):
4-Amino-N-(aminoiminomethyl)benzenesulfonamide, 4-Amino-N-guanylbenzenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C7H10N4O2S
CAS Number:
Molecular Weight:
214.24
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-345-9
Beilstein/REAXYS Number:
2695326
MDL number:
InChI
1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
InChI key
BRBKOPJOKNSWSG-UHFFFAOYSA-N
SMILES string
NC(=N)NS(=O)(=O)c1ccc(N)cc1
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
Quality Level
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfaguanidine may be used as an analytical reference standard for the determination of sulfaguanidine in:
- Food samples of animal origin by salting-out supported liquid extraction (SOSLE) and quick, easy, cheap, effective, rugged and safe (QuEChERS) extraction followed by analysis using nanoflow liquid chromatography high resolution mass spectrometry (LC-HRMS).
- Bovine muscle samples by hydrophilic interaction liquid chromatography-electrospray-tandem mass spectrometry (HILIC-ESI-MS/MS) equipped with selected reaction monitoring (SRM) mode of detection.
- Tissues, milk and eggs of food producing animals by ultrasound-assisted extraction (UAE), solid phase extraction (SPE) and LC-MS/MS.
- Beeswax by solid-liquid extraction (SLE), liquid-liquid extraction (LLE), SPE, QuEChERS extraction and ESI-LC-MS/MS with SRM detection.
General description
Chemical structure: sulfonamide
Sulfaguanidine belongs to the sulfonamide class of antibiotics. It can exhibit broad-spectrum inhibition of both gram-positive and gram-negative bacteria.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Determination of sulfonamides in beeswax by liquid chromatography coupled to tandem mass spectrometry.
Mitrowska K and Antczak M
Journal of Chromatography. B, Biomedical Sciences and Applications, 1006, 179-186 (2015)
Matrix-effect free multi-residue analysis of veterinary drugs in food samples of animal origin by nanoflow liquid chromatography high resolution mass spectrometry.
Alcantara-Duran J, et al.
Food Chemistry, 245, 29-38 (2018)
Alan D Gift et al.
Journal of pharmaceutical and biomedical analysis, 43(1), 14-23 (2006-08-03)
A moisture sorption gravimetric analyzer has been combined with a Raman spectrometer to better understand the various modes of water-solid interactions relevant to pharmaceutical systems. A commercial automated moisture sorption balance was modified to allow non-contact monitoring of the sample
T W Wong et al.
Journal of microencapsulation, 19(4), 511-522 (2002-10-25)
The potential application of pectin as a matrix polymer for making microspheres by an emulsification technique was explored, and the drug release property of these pectinate microspheres containing drug cores of varying aqueous solubilities: sulphanilamide, sulphaguanidine and sulphathiazole, was investigated
K Nakanishi et al.
Journal of pharmacobio-dynamics, 13(12), 760-765 (1990-12-01)
The influence of suppository bases and adjuvants on the release rate of drugs and the absorption of non-absorbable drugs such as sulfanilic acid (SA) and sulfaguanidine (SG), was investigated following the rectal administration of suppositories. The suppository bases used were
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