A3658
N8-Acetylspermidine dihydrochloride
analytical standard
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About This Item
Empirical Formula (Hill Notation):
C9H21N3O · 2HCl
CAS Number:
Molecular Weight:
260.20
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3698131
grade
analytical standard
Quality Level
technique(s)
mass spectrometry (MS): suitable
format
neat
storage temp.
2-8°C
SMILES string
Cl.Cl.CC(=O)NCCCCNCCCN
InChI
1S/C9H21N3O.2ClH/c1-9(13)12-8-3-2-6-11-7-4-5-10;;/h11H,2-8,10H2,1H3,(H,12,13);2*1H
InChI key
BWGUIRARVGYOIR-UHFFFAOYSA-N
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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M Lurdes et al.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 43(10), 990-994 (1989-11-01)
The synthesis of all three monoacetylated spermidines is reported. N4-Acetylspermidine was obtained in four steps from spermidine via the triacetylated intermediate by selective deacetylation after exhaustive t-butoxycarbonylation as well as directly from a previously described protected precursor. N1-Acetylspermidine and N8-acetylspermidine
Similarity of effects of N8-acetylspermidine and its deacetylase inhibitor on stimulating the growth of L1210 cells.
Z Wang et al.
Proceedings of the Western Pharmacology Society, 38, 41-43 (1995-01-01)
S W Snyder et al.
Biochemical and biophysical research communications, 180(2), 591-596 (1991-10-31)
The activity of two naturally occurring monoacetylated polyamines, N8-acetylspermidine and N1-acetylspermidine, as inducers of differentiation of HL60 human leukemia cells was assessed. Differentiation was quantified by morphological changes and the ability to reduce nitroblue tetrazolium. N8-Acetylspermidine produced 25-35 percent differentiation
M D Berry
Journal of neuroscience research, 55(3), 341-351 (1999-05-29)
The endogenous polyamines have been extensively studied with respect to their role in cellular death mechanisms, although the results are contradictory. In contrast, their primary metabolites, the N-acetyl polyamines, have not been much studied. It has been hypothesized that the
Sreenivasu Mudumba et al.
Biochemical pharmacology, 63(11), 2011-2018 (2002-07-03)
Spermidine is one of the simple polyamines found in cells of virtually all living organisms. It undergoes a metabolic conversion to N8-acetylspermidine catalyzed by an enzyme in cell nuclei and is converted back to spermidine by a deacetylase in the
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