(3-Glycidyloxypropyl)trimethoxysilane

(3-Glycidyloxypropyl)trimethoxysilane (GPTMS) is a high-purity, bifunctional organosilane designed for the seamless integration of biological molecules and organic polymers with inorganic substrates. This ≥98% purity grade is unique for its terminal epoxy (oxirane) ring, which enables "reagent-free" covalent bioconjugation via nucleophilic attack from amines, thiols, or hydroxyls. This reagent is the gold standard for stabilizing conductive polymers and creating 3D-networked hybrid scaffolds, offering a pH-selective reactivity profile that allows for controlled surface modification and superior optical clarity in thin-film applications.

As a versatile molecular bridge, GPTMS is essential for engineering intelligent interfaces and stimuli-responsive systems that enable precise interactions at the intersection of nanotechnology, biology, and electronics.


• Reagent-Free Bioconjugation: Enables direct immobilization of proteins, enzymes, and amino-modified DNA onto surfaces without secondary cross-linkers like EDC/NHS. • Conductive Polymer Stabilization: Enhances the electrical stability and mechanical adhesion of PEDOT:PSS films in bio-electronic sensors and neural interfaces. • Tissue Engineering Scaffolds: Functions as a critical cross-linker in chitosan-silica hybrids, significantly improving mechanical stability and biomineralization for bone regeneration. • Nanocarbon Reinforcement: Surface-modifies carbon nanotubes (MWCNTs) to optimize dispersion and interfacial bonding in high-performance nanocomposites for medical implants. • Enzyme Immobilization: Functionalizes silica and magnetic nanoparticles to create high-surface-area biocatalytic platforms for diagnostic assays and pharmaceutical synthesis.