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535311

Poly(N-isopropylacrylamide)

Mn ~40,000

Synonym(s):

NIPAM polymer, PNIPAM, Polyacrylamide, polyNIPAM

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About This Item

Linear Formula:
CH3(C6H11NO)nCH3
CAS Number:
25189-55-3
NACRES:
NA.23
PubChem Substance ID:
24877546
UNSPSC Code:
12162002
MDL number:
MFCD00284282
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Quality Level

100

mol wt

Mn 20,000-60,000, Mn ~40,000

mp

96 °C

SMILES string

CC(C)NC(=O)C=C

InChI

1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)

InChI key

WDFKEEALECCKTJ-UHFFFAOYSA-N

Application

PNIPAM-based Smart Surfaces for Cell Sheet Tissue Engineering
Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.

Physical form

Thermosensitive polymer, hydrogel

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

535311-BULK: + 535311-VAR: + 535311-10G:

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Certificates of Analysis (COA)

Lot/Batch Number
MKDB4998
0000491042
0000491042
MKCX8171
MKCV7874

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Articles

Functional Polymers for Biomedical Apps

Microparticles in drug delivery: Study on controlling chitosan microparticle size and distribution, exploring encapsulation of BSA and TPP cross-linker.

Designing Temperature and pH Sensitive NIPAM Based Polymers

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Smart Nanofiber Meshes as a Local Drug Delivery Platform

Professor Mitsuhiro Ebara provides insights on several types of smart nanofiber mesh systems that have been explored for different drug delivery purposes.

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Avraham Halperin et al.
Langmuir : the ACS journal of surfaces and colloids, 28(48), 16623-16637 (2012-11-06)
Thermoresponsive tissue culture substrates based on PNIPAM brushes are used to harvest confluent cell sheets for tissue engineering. The prospect of clinical use imposes the utilization of culture medium free of bovine serum, thus suggesting conjugation with adhesion peptides containing
Soichi Takagi et al.
Cell transplantation, 21(2-3), 411-420 (2012-07-17)
The de novo engineering of a uniform hepatocyte sheet in vitro is considered as a novel approach for liver-directed therapeutics. Hepatocytes can be cultured on a temperature-responsive culture dishes coated with poly(N-isopropylacrylamide) (PIPAAm). Following multiple days of culturing, the
Umut Atakan Gurkan et al.
Advanced healthcare materials, 1(5), 661-668 (2012-11-28)
Stimuli responsive, smart interface materials are integrated with microfluidic technologies creating new functions for a broad range of biological and clinical applications by controlling the material and cell interactions. Local capture and on-demand local release of cells are demonstrated with
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