Skip to Content
Merck

16-228

Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor™ 488

clone 4F11, Upstate®, from mouse

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
ALEXA FLUOR™ 488
Clone:
4F11, monoclonal
Application:
flow cytometry
immunocytochemistry
immunofluorescence
western blot
Species reactivity:
bovine, human, mouse, rat, hamster, avian
Citations:
24
Technique(s):
flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable
Uniprot accession no.:
Q14247

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor™ 488, clone 4F11, Upstate®, from mouse

biological source

mouse

conjugate

ALEXA FLUOR™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4F11, monoclonal

species reactivity

bovine, human, mouse, rat, hamster, avian

manufacturer/tradename

Upstate®

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_005231.2
NM_138565.1

UniProt accession no.

Q14247

shipped in

wet ice

Gene Information

human ... CTTN(2017)

Analysis Note

Control
Negative Control: Catalog # 16-240, Normal Mouse IgG, ALEXA FLUOR™ 488-conjugate.
Routinely evaluated by immunoblot.

Application

Detect Cortactin (p80/85) using this Anti-Cortactin (p80/85) Antibody, clone 4F11, Alexa Fluor 488 validated for use in FC, IF, WB & IC.
Research Category
Cell Structure
Research Sub Category
Cytoskeleton

Biochem/physiol Actions

Recognizes Cortactin in rodent and human cells

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Alexa Fluor is a registered trademark of Molecular Probes, Inc.

General description

Mr 80kDa and in avian cells, Mr 80kDa and 85kDa

Immunogen

Mixture of affinity-purified tyrosine phosphoproteins from chick embryo fibroblasts expressing activated pp60src

Physical form

Protein G Purified

Preparation Note

1 year at 4°C from date of shipment

Legal Information

ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

16-228:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration.
Gomathinayagam, R; Muralidharan, J; Ha, JH; Varadarajalu, L; Dhanasekaran, DN
Genes & Cancer null
C Dehio et al.
The EMBO journal, 14(11), 2471-2482 (1995-06-01)
Shigella flexneri causes bacillary dysentery in humans by invading epithelial cells of the colon. Cell invasion occurs via bacterium-directed phagocytosis, a process requiring polymerization of actin at the site of bacterial entry. We show that invasion of HeLa cells by
C Guinebault et al.
The Journal of cell biology, 129(3), 831-842 (1995-05-01)
Thrombin-induced accumulation of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) but not of PtdIns(3,4,5,)P3 is strongly correlated with the relocation to the cytoskeleton of 29% of the p85 alpha regulatory subunit of phosphoinositide 3-kinase (PtdIns 3-kinase) and is accompanied by a significant increase in
T Katsube et al.
The Journal of biological chemistry, 273(45), 29672-29677 (1998-10-29)
Cortactin is an actin filament-binding protein localizing at cortical regions of cells and a prominent substrate for Src family protein-tyrosine kinases in response to multiple extracellular stimuli. Human cortactin has been identified as a protein product of a putative oncogene
Actions by actin: reciprocal regulation of cortactin activity by tyrosine kinases and F-actin.
Gunst, Susan J
The Biochemical Journal, 380, e7-e8 (2004)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service