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218861

Casein Kinase II Inhibitor III, TBCA

Name: Casein Kinase II Inhibitor III, TBCA
Brand: MM

InSolution, ≥90%

Synonym(s):

InSolution Casein Kinase II Inhibitor III, TBCA, ( E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid

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About This Item

Empirical Formula (Hill Notation):

C₉H₄Br₄O₂

CAS Number:

934358-00-6

Molecular Weight:

463.74

UNSPSC Code:

12352200

NACRES:

NA.54

MDL number:

MFCD20921901

Assay:

≥90% (HPLC)

Form:

liquid

Storage condition:

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

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Properties

Quality Segment

100

assay

≥90% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

shipped in

dry ice

storage temp.

−70°C

SMILES string

OC(/C=C/C1=CC(Br)=C(Br)C(Br)=C1Br)=O

InChI

1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+

InChI key

SVJQCVOKYJWUBC-OWOJBTEDSA-N

Description

General description

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
CKII

Reversible: yes

Packaging

Packaged under inert gas

Physical form

A 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Other Notes

Pagano, M.A., et al. 2006. Chembiochem,8, 129.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (refers to pure substance)

flash_point_c

87 °C - closed cup - (refers to pure substance)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water insoluble liquid

fsl

218861-5MG:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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