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343922

5-Fluorouracil

≥98% (HPLC), solid, thymidylate synthase inhibitor, Calbiochem®

Synonym(s):

5-Fluorouracil, 5-FU

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About This Item

Empirical Formula (Hill Notation):
C4H3FN2O2
CAS Number:
51-21-8
Molecular Weight:
130.08
UNSPSC Code:
12171500
NACRES:
NA.77
MDL number:
MFCD00006018
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze
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Product Name

5-Fluorouracil, Potent antitumor agent.

description

Merck USA index - 14, 4181

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

hot water: 1 mg/mL, methanol: 1 mg/mL, DMF: 5 mg/mL, DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1[c]([nH][c]([nH]c1)=O)=O

InChI

1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key

GHASVSINZRGABV-UHFFFAOYSA-N

General description

Potent antitumor agent that inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis of human colon cancer cell lines.
Potent antitumor agent. Inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis in human colon cancer cell lines.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Aminoisobutyrate-pyruvate aminotransferase
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pressacco, J., et al. 1996. Br. J. Cancer72, 939.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H351

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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