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420355

Isoprenaline hydrochloride

≥99% (TLC), solid, β-adrenoceptor agonist, Calbiochem

Synonym(s):

Isoproterenol, Hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H17NO3 · xHCl
CAS Number:
51-30-9
Molecular Weight:
211.26 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00012603
Assay:
≥99% (TLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
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Product Name

Isoproterenol, Hydrochloride, Phenethylamine derivative.

description

Merck USA index - 14, 5217

Quality Segment

100

assay

≥99% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white to off-white, white

solubility

ethanol: soluble, water: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

[Cl-].N(C(C)C)CC(O)c1cc(c(cc1)O)O.[H+]

InChI

1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H

InChI key

IROWCYIEJAOFOW-UHFFFAOYSA-N

General description

Phenethylamine derivative. Selective β-adrenergic agonist that stimulates adenylate cyclase activity. Promotes glycogen breakdown and causes bronchodilation. Increases Cl– diffusion and potential difference in rabbit trachea cells through nitric oxide generation. Reported to activate MAP Kinase (ERK) by a Rap1 and B-Raf dependent process.

Biochem/physiol Actions

Cell permeable: no
Primary Target
β-adrenergic agonist
Product does not compete with ATP.
Reversible: no

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Schmitt, J.M., and Stork, P.J. 2000. J. Biol. Chem.275, 25342.
Carmena, M.J., et al. 1997. Prostate 33, 46.
Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274, 584.
Kishimoto, I., et al. 1994. J. Biol. Chem.269, 28300.
Macaulay, S.L., et al. 1994. Mol. Cell Biochem.141, 27.
Yashiro, K., et al. 1994. J. Biochem.115, 1040.
Ladenheim, R.G., et al. 1993. J. Neurochem.60, 260.
von Zastrow, M., et al. 1993. J. Biol. Chem.268, 763.
Mokhtari, A., et al. 1985. J. Cyclic Nucleotide Protein Phosphorylation Res.10, 213.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

No data available

flash_point_c

No data available

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

420355-MG: + 420355-100MG: + 420355-0GM:

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