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438210

LSF Inhibitor, FQI1

Name: LSF Inhibitor, FQI1
Brand: MM

The LSF Inhibitor, FQI1 controls the biological activity of LSF.

Synonym(s):

LSF Inhibitor, FQI1, (±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₇NO₄

Molecular Weight:

311.33

UNSPSC Code:

12352200

NACRES:

NA.28

MDL number:

MFCD03632583

Assay:

>92% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Quality Level

100

assay

>92% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

N1c2c(cc4c(c2)OCO4)C(CC1=O)c3c(cccc3)OCC

InChI

1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20)

InChI key

YKSYGLXHLSPWLB-UHFFFAOYSA-N

Description

General description

A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC₅₀ = 2.1 µM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI₅₀ = 3.8, 0.79, and 6.3 µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Grant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA109, 4503.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

438210-10MG: + 438210-MG:

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Certificates of Analysis (COA)

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Global Trade Item Number

SKU	GTIN
438210-10MGCN	04055977187052