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AB5384

Anti-Nitric Oxide Synthase II Antibody

serum, Chemicon®

Synonym(s):

NOS II, iNOS

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
10
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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

NM_000625.3, NM_153292.1

UniProt accession no.

P35228

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... NOS2(4843)

General description

The inducible isoform of the enzyme nitric oxide synthase (iNOS, NOS-II) is synthesized by macrophages and many other cell types in response to proinflammatory cytokines and certain other stimuli, such as hypoxia and stress.

Immunogen

C-terminal 19 amino acid peptide from human chondrocyte nitric oxide synthase.

Application

Detect Nitric Oxide Synthase II using this Anti-Nitric Oxide Synthase II Antibody validated for use in WB, IH.
Research Category
Neuroscience
Research Sub Category
Oxidative Stress
Western blot: 1:1,000-1:2,500 (ECL).

Immunohistochemistry: 1:2,500-1:6,000 (ABC).

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Inducible nitric oxide synthase (iNOS, NOS-II). No cross-reaction with nNOS and eNOS by immunohistochemistry. AB5384 reacts with human glia and certain neurons in Alzheimer′s disease by immunohistochemistry.

Physical form

Rabbit serum. Liquid containing 0.05% sodium azide.

Preparation Note

Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

AB5384:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Related Content

White Paper- Modern Methods in Oxidative Stress Research

"Redox reactions are powerful chemical processes that involve the reduction and oxidation of proteins and metabolites found in living things. The mechanisms that regulate them are key to maintaining homeostasis and the balance between good health and disease pathology. Oxidative stress is the state where the delicate balance of redox biology is upset, and the pathology of oxidative stress are the cellular consequences to such an imbalance."

RABBIT ANTI-INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS)
PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD
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Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.
Schuh, C; Wimmer, I; Hametner, S; Haider, L; Van Dam, AM; Liblau, RS; Smith, KJ; Probert et al.
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Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron.
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Global Trade Item Number

SKUGTIN
AB538404053252470691