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AB9983

Anti-Tyrosine Hydroxylase Antibody

rabbit polyclonal

Synonym(s):

Tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
Species reactivity:
rat, mouse
Application:
IHC, WB
Citations:
10
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Product Name

Anti-Tyrosine Hydroxylase Antibody, from rabbit

biological source

rabbit

Quality Segment

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, mouse

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

NCBI accession no.

NP_000351.2

UniProt accession no.

P07101

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Th(21823)
rat ... Th(25085)

General description

Tyrosine Hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.
~ 58 kDa

Immunogen

Epitope: C-terminus
Recombinant protein

Application

Anti-Tyrosine Hydroxylase Antibody detects level of Tyrosine Hydroxylase & has been published & validated for use in IH(P) & WB.
Immunohistochemistry: 1:100 working dilutions were used on rat and mouse brain (paraffin embedded tissue).
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Biochem/physiol Actions

Cat. # AB9983 recognizes the C-terminus of Tyrosine Hydroxylase
Reactivity with other species has not been determined.

Physical form

Antigen Affinity Purified
Format: Purified
Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3

Preparation Note

Stable for 1 year at 2-8ºC from date of receipt.

Analysis Note

Control
Rat Brain lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

AB9983:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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