MILLIPLEX^® Human CD8+ T Cell Panel Serum-Free

CD8+ T cells (also known as cytotoxic T cells, cytolytic T cells and killer T cells) belong to a sub-group of T cells capable of inducing the death of infected somatic or tumor cells. T cells that bind weakly to Major Histocompatibility Complex (MHC) self-antigens are positively selected into single-positive CD4+ or CD8+ T cells in the thymus. Those CD8+ T cells that survive and mature after activation become cytotoxic cells, expressing T-cell receptors (TCRs) capable of recognizing specific antigenic peptides bound to Class I MHC molecules and the glycoprotein CD8. Affinity between the CD8 protein and the MHC molecule helps to keep the cytotoxic T cell and target closely bound during antigen specific activation. Once activated, CD8+ T cells are generally classified as having a predefined cytotoxic role within the immune system and undergo IL-2 induced clonal expansion, which increases the number of cells specific for the target antigen. The CD8+ T cells then travel throughout the body in search of antigen-positive somatic/tumor cells.

Simultaneously analyze up to 17 analytes in human cell culture supernatants.

Analytes included: GM-CSF, sCD137, IFNγ, sFas, sFasL, Granzyme A, Granzyme B, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, MIP-1α, MIP-1β, TNF-α, Perforin

• Enhanced Understanding of Immune Response: The ability to measure multiple cytokines and chemokines associated with CD8+ T cell activity aids researchers in understanding the immune response in various conditions, including infections and cancers.
• Streamlined Research Process: The overnight run time and simple sample preparation facilitate a more efficient research workflow, allowing for quicker data analysis and decision-making.
• Configurable Options for Diverse Research Needs: The ability to configure the panel ensures that researchers can adapt the kit to their specific study requirements, making it a versatile tool in immunology research.
• Comprehensive Analyte Detection: The panel includes 15 key analytes relevant to CD8+ T cell function and activity, such as GM-CSF, IFNγ, IL-2, Granzyme A, and Perforin, allowing for a detailed immune response analysis.
• Designed for Human Cell Culture Supernatants: Optimized for analyzing CD8+ T cell markers in cell culture supernatants.

Luminex is a registered trademark of Luminex Corporation

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

For research use only. Not for use in diagnostic procedures.

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By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.