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Merck

IL038

Interleukin-1β Protein, Recombinant human

The recombinant human Interleukin-1beta protein (or IL-1beta protein) is a potent immuno-modulator which mediates a wide range of immune & inflammatory responses including the activation of B & T-cells.

Synonym(s):

IL-1beta

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.75
eCl@ss:
32160405
Assay:
>98% (SDS-PAGE and HPLC)
Biological source:
human

Key Documents

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Product Name

Interleukin-1β Protein, Recombinant human, The recombinant human Interleukin-1beta protein (or IL-1beta protein) is a potent immuno-modulator which mediates a wide range of immune & inflammatory responses including the activation of B & T-cells.

biological source

human

assay

>98% (SDS-PAGE and HPLC)

specific activity

>1 x 10e9 U/mg

manufacturer/tradename

Chemicon®

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 ng/μg endotoxin (of human IL-1beta; 1EU/μg)

input

sample type hematopoietic stem cell(s)

NCBI accession no.

NM_000576.2

UniProt accession no.

P01584

shipped in

dry ice

Quality Level

100

Related Categories

Analysis Note

Specific Activity: Chemicon′s human IL-1beta is fully biologically active when compared to standards.The ED(50) as determined by the dose-dependent stimulation of the proliferation of murine D10S cells is <0.001 ng/mL

Application

For most in vitro applications, human IL-1beta is fully biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): Leukocytes.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Interleukin-1beta (IL-1beta) is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T-cells. Human IL-1beta is a 17.3 kDa protein containing 153 amino acid residues.

Physical form

Sterile filtered and lyophilized from 10 mM Tris, pH 8.2 with no preservatives.

Preparation Note

The lyophilized human IL-1beta, though stable at room temperature, is best stored desiccated at -20°C. After a quick spin, reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions. Reconstituted human IL-1beta should be stored in undiluted aliquots at -20°C for up to six months.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

IL038:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Byounghoon Brian Hwang et al.
Communications biology, 3, 8-8 (2020-01-08)
Monitoring cellular signaling events can help better understand cell behavior in health and disease. Traditional immunoassays to study proteins involved in signaling can be tedious, require multiple steps, and are not easily adaptable to high throughput screening (HTS). Here, we
Monika E Czerwińska et al.
Plants (Basel, Switzerland), 10(11) (2021-11-28)
Fruits of Cornus mas and Cornus officinalis are representative plant materials traditionally used in Europe and Asia, respectively, in the treatment of diabetes and diabetes-related complications, which are often mediated by pathogenic inflammatory agents. Additionally, due to the fact of
Lijun Zhu et al.
Cells, 11(10) (2022-05-29)
Toxoplasma gondii is a common opportunistic protozoan pathogen that can parasitize the karyocytes of humans and virtually all other warm-blooded animals. In the host's innate immune response to T. gondii infection, inflammasomes can mediate the maturation of pro-IL-1β and pro-IL-18
Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF.
Defois, et al.
Cell communication and signaling : CCS, 21, 137-137 (2023)
Rojo A Ratsimandresy et al.
Nature communications, 8, 15556-15556 (2017-06-06)
Inflammasomes are protein platforms linking recognition of microbe, pathogen-associated and damage-associated molecular patterns by cytosolic sensory proteins to caspase-1 activation. Caspase-1 promotes pyroptotic cell death and the maturation and secretion of interleukin (IL)-1β and IL-18, which trigger inflammatory responses to

Global Trade Item Number

SKUGTIN
IL03804053252733123

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