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Merck

178494

Apoptosis Inhibitor II, NS3694

The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Apoptosis Inhibitor II, NS3694, NS3694

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About This Item

Empirical Formula (Hill Notation):
C15H10ClF3N2O3
CAS Number:
426834-38-0
Molecular Weight:
358.70
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00249000

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Product Name

Apoptosis Inhibitor II, NS3694, The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

SMILES string

FC(F)(F)c1cc(ccc1)NC(=O)Nc2c(ccc(c2)Cl)C(=O)O

InChI

1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)

InChI key

GNCZTZCPXFDPLI-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 10 mg/mL
ethanol: slightly soluble

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Apoptosome complex formation
Product does not compete with ATP.
Reversible: no
Target IC50: 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable diarylurea compound that specifically prevents the formation of the active ~700 kDa apoptosome complex induced by cytochrome c release. Alters cytochrome c and ATP-triggered association between Apaf-1 and caspase-9. Protects against apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by Fas ligand (FasL). Does not inhibit cytochrome c release or the activity of caspase-3 and -9.

Other Notes

Lademann, U., et al. 2003. Mol. Cell. Biol.23, 7829.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
178494-10MGCN04055977204803

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