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Merck

5.04359

Palmitoylethanolamide

Synonym(s):

Palmitoylethanolamide, N-(2-Hydroxyethyl)hexadecanamide, PEA, Palmidrol

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About This Item

Empirical Formula (Hill Notation):
C18H37NO2
CAS Number:
544-31-0
Molecular Weight:
299.49
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD00020562

Key Documents

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form

solid

SMILES string

N(CCO)C(=O)CCCCCCCCCCCCCCC

InChI

1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)

InChI key

HXYVTAGFYLMHSO-UHFFFAOYSA-N

assay

≥99% (HPLC)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 20 mM

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Primary Target
GPR55 receptor

Disclaimer

Toxicity: Standard Handling (A)

General description

An endogenous lipid that acts as a selective agonist for GPR55 receptors (EC50 = 4, 19 800 and >30 000 nM at GPR55, CB2 and CB1 receptors respectively). Producing robust anti-inflammatory actions by activating PPARα (EC50 = 3 µM).

Other Notes

Griffin, G., et al. 2000. J. Pharmacol. Exp. Ther.292, 886.

Lambert, D., et al. 2001. Epilepsia.42, 321.
Lambert, D., et al. 2002. Curr. Med. Chem.9, 663.
Lo Verme, J., et al. 2005. Life Sci.77, 1685.
Re, G., et al. 2005. Vet. J.173, 21.
Ryberg, R., et al. 2007. Br. J. Pharmacol.152, 1092.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Slight warming is required for complete solubilization.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

CorrosionEnvironment
GHS05,GHS09

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
5.04359.000104055977263978

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