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Merck

FCMAB108A4

Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor™ 488

clone 5D11G5, from mouse, ALEXA FLUOR™ 488

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
ALEXA FLUOR™ 488
Clone:
5D11G5, monoclonal
Application:
FACS, WB
Citations:
-

Key Documents

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biological source

mouse

conjugate

ALEXA FLUOR™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

5D11G5, monoclonal

species reactivity

human, Xenopus, bovine

technique(s)

flow cytometry: suitable, western blot: suitable

isotype

IgG1

NCBI accession no.

NM_006306

UniProt accession no.

Q14683

shipped in

wet ice

target post-translational modification

phosphorylation (pSer957)

Quality Level

100

Gene Information

human ... SMC1A(8243)

Related Categories

General description

150kDa Calculated
SMC (structural maintenance of chromosomes) proteins are Involved in chromosome cohesion during cell cycle and in DNA repair. ATM phosphorylates SMC1 on Ser957 and Ser966 both in vitro and in vivo. Phosphorylated SMC1 is part of the complex that functions as a downstream effector in both the ATM/NBS1 branch and the ATR/MSH2 branch of S-phase checkpoint.

Immunogen

Epitope: Phosphorylated at and around Ser957
KLH-conjugated, synthetic peptide corresponding to human SMC1 phosphorylated at Ser957

Application

Research Category
Epigenetics & Nuclear Function

Apoptosis & Cancer
Research Sub Category
Cell Cycle, DNA Replication & Repair
This Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor 488 is validated for use in WB, FC for the detection of phospho-SMC1 (Ser957).

Biochem/physiol Actions

Antibody recognizes SMC1 phosphorylolated at Ser957.
Predicted to cross-react with xenopus and bovine based on sequence homology

Physical form

Protein G Purified
Purified mouse monoclonal IgG1 conjugated to Alexa Flour 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Preparation Note

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months from date of receipt. Protect from light.

Analysis Note

Control
HeLa Cells
Evaluated by Flow Cytometry with Hela Cells

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FCMAB108A4:

jan

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Global Trade Item Number

SKUGTIN
FCMAB108A404053252472855

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