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Merck

A6559

Adenosine 5′-triphosphate disodium salt solution

≥95% (HPLC), liquid

Synonym(s):

ATP

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About This Item

CAS Number:
987-65-5
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24891106
NACRES:
NA.52
MDL number:
MFCD00080339
Assay:
≥95%
Biological source:
yeast
Form:
liquid
Storage temp.:
−20°C

Key Documents

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Product Name

Adenosine 5′-triphosphate disodium salt solution, Crystalline ATP, HPLC purified, aqueous solution for RNA transcription

SMILES string

[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

InChI key

TTWYZDPBDWHJOR-IDIVVRGQSA-L

biological source

yeast

assay

≥95%

form

liquid

concentration

100 mM in H2O (adjusted to pH 7 with Trizma®
base)

foreign activity

DNase, RNase, none detected

shipped in

dry ice

storage temp.

−20°C

Quality Level

300

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General description

Adenosine 5′-triphosphate disodium salt solution is suitable for use in molecular biology applications such as kinase reactions or DNA-dependent RNA polymerase transcription.

Application

Adenosine 5′-triphosphate disodium salt solution has been used:
  • as a standard to evaluate the extracellular ATP release from marginal cells of stria vascular
  • as a component of the internal pipette solution to establish a recording electrode to study neurite stretching
  • in in vitro VPS34 (catalytic subunit of the phosphatidylinositol 3-kinase (PtdIns3K) complex) activity assay
  • as a component of lysis and resealing buffers for ATP studies
  • in spectrophotometric measurement of H+ transport in fluorescein isothiocyanate (FITC)-dextran loaded A549 (adenocarcinomic human alveolar basal epithelial cells) and HeLa cells
  • to induce pyroptosis in lipopolysaccharide treated fibroblast-like synoviocytes (FLSs)

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is an important energy currency in all living organisms. It possesses high phosphate transfer potential. ATP is involved in several biological processes such as membrane transport, muscle contraction and synthesis, and degradation of biological molecules. It plays a role as an intracellular and extracellular signaling molecule in certain cellular processes such as cell motility, organ development, neurotransmission, and insulin secretion.

Legal Information

Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

A6559-1VL-KC: + A6559-25UMO: + A6559-VAR: + A6559-25UMO-KC: + A6559-BULK: + A6559-250UMO-KC:

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Certificates of Analysis (COA)

Lot/Batch Number
0000486710
0000486710
0000394151
0000366958
0000394151

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Cooper GM
The Cell: A Molecular Approach (2000)
Yahui Huang et al.
Archiv der Pharmazie (2018-06-29)
Inhibition of spleen tyrosine kinase (Syk) is a promising strategy for the treatment of various allergic and autoimmune disorders such as asthma, rheumatoid arthritis, and allergic rhinitis. Previously, a Syk inhibitor with novel indazole scaffold was discovered by structure-based virtual
James Franklin Tucker et al.
PLoS genetics, 12(2), e1005873-e1005873 (2016-02-20)
Epigenetic gene silencing plays a critical role in regulating gene expression and contributes to organismal development and cell fate acquisition in eukaryotes. In fission yeast, Schizosaccharomyces pombe, heterochromatin-associated gene silencing is known to be mediated by RNA processing pathways including
Hiromi Imamura et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(37), 15651-15656 (2009-09-02)
Adenosine 5'-triphosphate (ATP) is the major energy currency of cells and is involved in many cellular processes. However, there is no method for real-time monitoring of ATP levels inside individual living cells. To visualize ATP levels, we generated a series
Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.
Farkas T
The Journal of Biological Chemistry, 286(45), 38904-38912 (2011)
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Product Information Sheet - A6559

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